ID R4YV53_OLEAN Unreviewed; 134 AA.
AC R4YV53;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Cyclic diguanosine monophosphate-binding protein {ECO:0000256|PIRNR:PIRNR028141};
DE Short=c-di-GMP-binding protein {ECO:0000256|PIRNR:PIRNR028141};
DE AltName: Full=Pilz domain-containing protein {ECO:0000256|PIRNR:PIRNR028141};
GN ORFNames=OLEAN_C34230 {ECO:0000313|EMBL:CCK77599.1};
OS Oleispira antarctica RB-8.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae; Oleispira.
OX NCBI_TaxID=698738 {ECO:0000313|EMBL:CCK77599.1, ECO:0000313|Proteomes:UP000032749};
RN [1] {ECO:0000313|EMBL:CCK77599.1, ECO:0000313|Proteomes:UP000032749}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23877221; DOI=10.1038/ncomms3156;
RA Kube M., Chernikova T.N., Al-Ramahi Y., Beloqui A., Lopez-Cortez N.,
RA Guazzaroni M.E., Heipieper H.J., Klages S., Kotsyurbenko O.R., Langer I.,
RA Nechitaylo T.Y., Lunsdorf H., Fernandez M., Juarez S., Ciordia S.,
RA Singer A., Kagan O., Egorova O., Petit P.A., Stogios P., Kim Y.,
RA Tchigvintsev A., Flick R., Denaro R., Genovese M., Albar J.P., Reva O.N.,
RA Martinez-Gomariz M., Tran H., Ferrer M., Savchenko A., Yakunin A.F.,
RA Yakimov M.M., Golyshina O.V., Reinhardt R., Golyshin P.N.;
RT "Genome sequence and functional genomic analysis of the oil-degrading
RT bacterium Oleispira antarctica.";
RL Nat. Commun. 4:2156-2156(2013).
CC -!- FUNCTION: Binds the second messenger bis-(3'-5') cyclic dimeric
CC guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per
CC monomer. May play a role in bacterial second-messenger regulated
CC processes. Binding to c-di-GMP induces a conformational change of the
CC C- and N-termini resulting in the exposure of a highly negative surface
CC on one side of the protein to a possible effector protein.
CC {ECO:0000256|PIRNR:PIRNR028141}.
CC -!- SUBUNIT: Monomer in both c-di-GMP-bound and free forms.
CC {ECO:0000256|PIRNR:PIRNR028141}.
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DR EMBL; FO203512; CCK77599.1; -; Genomic_DNA.
DR AlphaFoldDB; R4YV53; -.
DR STRING; 698738.OLEAN_C34230; -.
DR KEGG; oai:OLEAN_C34230; -.
DR HOGENOM; CLU_146776_0_0_6; -.
DR OrthoDB; 5298508at2; -.
DR Proteomes; UP000032749; Chromosome.
DR GO; GO:0035438; F:cyclic-di-GMP binding; IEA:InterPro.
DR Gene3D; 2.40.10.220; predicted glycosyltransferase like domains; 1.
DR InterPro; IPR027021; C-di-GMP_BP_PA4608.
DR InterPro; IPR009875; PilZ_domain.
DR Pfam; PF07238; PilZ; 1.
DR PIRSF; PIRSF028141; C-di-GMP_BP_PA4608; 1.
DR SUPFAM; SSF141371; PilZ domain-like; 1.
PE 4: Predicted;
KW c-di-GMP {ECO:0000256|PIRNR:PIRNR028141};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR028141};
KW Reference proteome {ECO:0000313|Proteomes:UP000032749}.
FT DOMAIN 11..113
FT /note="PilZ"
FT /evidence="ECO:0000259|Pfam:PF07238"
SQ SEQUENCE 134 AA; 15117 MW; 1FBFF41940491C27 CRC64;
MSDQNLENTH ENRRFRRISF VEAVQVVSED VDGAEACSWE AQCIDISMLG MLLAVPEGFP
LVIGTPFEVQ LILAEDVMIE MPCTLVHIEG HRAGFRSEMM SIDSLTNLRR LLELNLADNI
EVERELAELI KQSS
//
