ID R5B7P0_9BACT Unreviewed; 807 AA.
AC R5B7P0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Putative tyrosine-protein kinase ptk {ECO:0000313|EMBL:CCX51600.1};
GN ORFNames=BN689_01438 {ECO:0000313|EMBL:CCX51600.1};
OS Alistipes sp. CAG:514.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Rikenellaceae;
OC Alistipes.
OX NCBI_TaxID=1262696 {ECO:0000313|EMBL:CCX51600.1, ECO:0000313|Proteomes:UP000018254};
RN [1] {ECO:0000313|EMBL:CCX51600.1, ECO:0000313|Proteomes:UP000018254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:514 {ECO:0000313|Proteomes:UP000018254};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCX51600.1}.
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DR EMBL; CAWO010000041; CCX51600.1; -; Genomic_DNA.
DR AlphaFoldDB; R5B7P0; -.
DR STRING; 1262696.BN689_01438; -.
DR Proteomes; UP000018254; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CCX51600.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018254};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 31..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..111
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 446..520
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 599..721
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 807 AA; 88969 MW; BCD37C1FE7529048 CRC64;
MENNINTDNN TRQQEETVQI GQLVRRCLSR WYWFALSLAV CLALGALYIL RSTPTYNTSA
DIQIKSNTKG ASMPGDIGEF GNMGLFAVKS NVNNELHAFE SPDIMSEVVA RLRLYMSYTV
DGTFHRNVLY GTSLPISADL LDVDENVGVG FTVSENGGRV TLNDFIHKNE KVGGKPVVGH
YGDTLQTPVG RIIVQKTKDY SGEAMKKPVN VRKSGQRGVT QSYLNRLQVN LADKNADVIS
LSIKDVSTQR AQDILNTLIA VYNENWVRDK NQIANSTSVF INDRLRVIEG ELAGVDSDIS
AYKSENMIPD VGAAATMYMQ QSTVLNQQLQ DVSNQLYMAR YIKDYIGKED NRNQPLPANM
GLSSQTIENG ISEYNSKILQ RNNLVANSGE ENVLVKDLDQ ALASMRGSIS RSIDNEILAL
NTKYENLKGT ARQNTARIAA NPNQAKQLLS VERQQTVKQA LYLFLLQKRE ENELSQAFTA
YNTRIIKHPI SGIFPVSPQS MKIMMMAFLL GLMIPAGIIY LLMATDTKVR SRRDLKGVSV
PFAGEIPLSA ETATKAFGKR KTLSGADSIV VRHGNRNVVN EAFRVLRTNF EFTMREPGSK
VIAVTSFSPG AGKSFVSSNL AVCFAIKGKR VLVIDGDLRH ATLSELVGSP KPGLSDYLAG
IVADVHDVIV RSKDAMTVPD ILPAGSIPPN PVELLADRRL ADAIAVLRNE YDVIIIDCPP
VEIVTDARVI NDYVDRTLFV VRAGQFDKAM LPDLDVLYRD GEYRGLCCVL NGTASSDGYY
GNYGTYGHYG YYGHNGGSYY SSDNKAR
//
