ID R5DZ69_9FIRM Unreviewed; 561 AA.
AC R5DZ69;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Protease CspB {ECO:0000313|EMBL:CCX81892.1};
GN ORFNames=BN798_01448 {ECO:0000313|EMBL:CCX81892.1};
OS Eubacterium sp. CAG:86.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1262895 {ECO:0000313|EMBL:CCX81892.1, ECO:0000313|Proteomes:UP000017940};
RN [1] {ECO:0000313|EMBL:CCX81892.1, ECO:0000313|Proteomes:UP000017940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:86 {ECO:0000313|Proteomes:UP000017940};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCX81892.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CAXC010000041; CCX81892.1; -; Genomic_DNA.
DR AlphaFoldDB; R5DZ69; -.
DR Proteomes; UP000017940; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07478; Peptidases_S8_CspA-like; 1.
DR Gene3D; 2.60.120.1290; -; 1.
DR Gene3D; 3.30.70.2980; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR041365; CspB_prodomain.
DR InterPro; IPR034045; Pep_S8_CspA-like.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF18425; CspB_prodomain; 1.
DR Pfam; PF00082; Peptidase_S8; 2.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000017940};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}.
FT DOMAIN 4..93
FT /note="Csp protease B prodomain"
FT /evidence="ECO:0000259|Pfam:PF18425"
FT DOMAIN 123..341
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT DOMAIN 430..553
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT ACT_SITE 132
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 193
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 498
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 561 AA; 61332 MW; 2CC294F22189EEF1 CRC64;
MANQKLETLL NVSMQATQED RAKSPDLSAG VDEEAGIWEI IVKYTQDLSQ FSAKYPGMEI
YELLGGYAII KIKKEYIDSL SQEKQIQFIE KPKRLYFQLS NEKSAACITP VQAGSDNPYG
LFGEGVITAI IDSGIDVTNP DFKNENGTTR IIGIWDQDRD IFYDSSQIDR YLDGENPKGM
HAQRAPGFDI SGHGTNVARI ACGNRGVASK SDILVVKMGN TDRTSFSGTT QLIKGVDFCI
KKAADLGKPV AINISYGNNY GDHSGSSIQE SFINTASASW KCAICVGSGN EGLGAGHTSG
RLRQGEEQYV QIAVSEYETS LNIQIWKDYW DDFNIEVITP AGINLGRISR YNTLNTVSTG
TEKVLCYYAQ PLPFSMRQEI YIDIVPVNNY ITSGLWRINF IPDKIRTGFF DMWLPAAASL
NSKTGFTRPD SSLTYTVPST SSNVITVGSY NAATNTPSPF SGRGYVTQSE SGIAVKPDIV
APGENVRIDE RTIVSGTSYA VPFVTGASAL LMEWGIVRGN DLFLYGEKLK AHLIKGSLPL
NGMNIPDDVT GWGKMCMAQS I
//
