ID R5E693_9FIRM Unreviewed; 380 AA.
AC R5E693;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Cobalamin biosynthesis protein CobW {ECO:0008006|Google:ProtNLM};
GN ORFNames=BN798_00455 {ECO:0000313|EMBL:CCX84302.1};
OS Eubacterium sp. CAG:86.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1262895 {ECO:0000313|EMBL:CCX84302.1, ECO:0000313|Proteomes:UP000017940};
RN [1] {ECO:0000313|EMBL:CCX84302.1, ECO:0000313|Proteomes:UP000017940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:86 {ECO:0000313|Proteomes:UP000017940};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCX84302.1}.
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DR EMBL; CAXC010000138; CCX84302.1; -; Genomic_DNA.
DR AlphaFoldDB; R5E693; -.
DR Proteomes; UP000017940; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748:SF62; COBW DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR Pfam; PF02492; cobW; 1.
DR Pfam; PF07683; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000017940}.
FT DOMAIN 4..179
FT /note="CobW/HypB/UreG nucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF02492"
FT DOMAIN 294..378
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07683"
SQ SEQUENCE 380 AA; 43116 MW; BC9F9EE1069A3C02 CRC64;
MTKVDIISGF LGAGKTTLIS KLLKEALPDE QVVLIENEFG EIGIDGGFLK DSGVEIREMN
SGCICCSLVG DFGTSLKEVV DKYHPDRIII EPSGVGKLSD VIKAVKDLHI ENEIRLNSAS
TVADASKVKM YMKNFGEFFN NQIEHAGTII LSRTQNVSED KLKKAIEMIR SLNADAHIIT
TPWDSLDGKQ ILAAMENVTN LELEMLAEQA EKTHEEHEHE HHHHDGECCC GHHHDDDEEH
EHHHHDHDDE CCHHDHDHEH EHHHHDHDGE CCHHDHDHEH HHHEGHHHAD DVFTSWGEET
PNKYDKEALD AILKKLANTN EYGSILRAKG MLPANDGTWM YFDLVPEEYE IREGNPDYTG
RICVIGAELK EDALKELFNL
//
