ID   R5GJW9_9FIRM            Unreviewed;       261 AA.
AC   R5GJW9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Segregation and condensation protein A {ECO:0000256|HAMAP-Rule:MF_01805};
GN   Name=scpA {ECO:0000256|HAMAP-Rule:MF_01805};
GN   ORFNames=BN498_01087 {ECO:0000313|EMBL:CCY13092.1};
OS   Eubacterium sp. CAG:146.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1262879 {ECO:0000313|EMBL:CCY13092.1, ECO:0000313|Proteomes:UP000018404};
RN   [1] {ECO:0000313|EMBL:CCY13092.1, ECO:0000313|Proteomes:UP000018404}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:146 {ECO:0000313|Proteomes:UP000018404};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in chromosomal partition during cell division.
CC       May act via the formation of a condensin-like complex containing Smc
CC       and ScpB that pull DNA away from mid-cell into both cell halves.
CC       {ECO:0000256|HAMAP-Rule:MF_01805}.
CC   -!- SUBUNIT: Component of a cohesin-like complex composed of ScpA, ScpB and
CC       the Smc homodimer, in which ScpA and ScpB bind to the head domain of
CC       Smc. The presence of the three proteins is required for the association
CC       of the complex with DNA. {ECO:0000256|HAMAP-Rule:MF_01805}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01805}.
CC       Note=Associated with two foci at the outer edges of the nucleoid region
CC       in young cells, and at four foci within both cell halves in older
CC       cells. {ECO:0000256|HAMAP-Rule:MF_01805}.
CC   -!- SIMILARITY: Belongs to the ScpA family. {ECO:0000256|HAMAP-
CC       Rule:MF_01805}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCY13092.1}.
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DR   EMBL; CAXQ010000050; CCY13092.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5GJW9; -.
DR   Proteomes; UP000018404; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 6.10.250.2410; -; 1.
DR   Gene3D; 1.10.10.580; Structural maintenance of chromosome 1. Chain E; 1.
DR   HAMAP; MF_01805; ScpA; 1.
DR   InterPro; IPR003768; ScpA.
DR   InterPro; IPR023093; ScpA-like_C.
DR   PANTHER; PTHR33969; SEGREGATION AND CONDENSATION PROTEIN A; 1.
DR   PANTHER; PTHR33969:SF2; SEGREGATION AND CONDENSATION PROTEIN A; 1.
DR   Pfam; PF02616; SMC_ScpA; 1.
PE   3: Inferred from homology;
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_01805};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_01805};
KW   Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP-
KW   Rule:MF_01805}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01805};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018404}.
SQ   SEQUENCE   261 AA;  31036 MW;  7106AA97D85B536E CRC64;
     MIERDLEQSM KLEQSMKIDI KLDVFEGPLD LLLHLIEKNK VSIYDIPIVE ITNQYMEYIR
     EMEKSYSMES MSEFLVMAAT LLKIKSKMLL PQPEKEEEED PREELVRRLT EYKIYKYAAE
     ELKDLSVDAQ KVFFKSETVP EEIKHYEEPI RPGEIVGDVT LEKLNQIFQM VMRRKKDRED
     PVRSQFGKIQ KEKYKVEDRM DDIRCQIRGL KRINFRTLLD IQPVKEMVIV TFLAVLELMK
     VGEVKVVQEH NFAEIYLDSC E
//