ID R5JG39_9BACE Unreviewed; 964 AA.
AC R5JG39;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=BN523_03666 {ECO:0000313|EMBL:CCY51734.1};
OS Bacteroides sp. CAG:189.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1262737 {ECO:0000313|EMBL:CCY51734.1, ECO:0000313|Proteomes:UP000018406};
RN [1] {ECO:0000313|EMBL:CCY51734.1, ECO:0000313|Proteomes:UP000018406}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:189 {ECO:0000313|Proteomes:UP000018406};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCY51734.1}.
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DR EMBL; CAYI010000207; CCY51734.1; -; Genomic_DNA.
DR RefSeq; WP_005928388.1; NZ_HF991125.1.
DR AlphaFoldDB; R5JG39; -.
DR Proteomes; UP000018406; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000018406};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 313..599
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 964 AA; 111743 MW; 93650292B422629C CRC64;
MPIAHFERKI QELNFSFISE KGTSGVLLTQ NYESLSKAIS APDILFALET AKNKFGADAV
YFRYFQDSRA AVPQLYIFDY TLKPLSSQEK NRIHRNMWNG YQVPVYIIIE KSSVSFFDAR
EKPDYNRVNY AQEIIIKTGE AIRNFNAQSF DNGLFWEEEI NKNHFQFEQS ATKDLIRGLK
EVYASFQKES GLDKHVALKL LVQCLLIKYL EERDEDSQSG YFASTYFQKH FQCNGFCDVI
RQGKLLDLLD KLASDFNGKI FQWDKEKEVK ERTSIRKTEI KYLANYLDAN IENNQYVFWR
LYSFSHLPVE VISSVYEELL TDSKDIVYTP EMIVSTLVDE CMPLQSPQKD FKLIDVSCGS
GIFLVKAYKR IVQWWRYEQW QKTGKLEKPS LPVLKDLLLK SIHGVDIEQD AIRLSIFSLA
LAILDEVNLD SPTWGELKFP DLNNNIITKN FFKYVTENPP NDFSLVIGNP PFNLPFVNDK
EPARKEYFKK LEKQFGYKTE IDIPDENPAL HFLVQSMKLL KAGGILSMIQ PSGPLLYQKD
LKFKEDVFST YNLLQVIDFT KLADKLWGKK NVSTAAVFLQ KSRPDSEPVL HLIANRTFSN
ANKLFLEFDY YDFHFMSKND AIFKPYTWKA HLLGGGRITS LIERLSTLPT LKEFLKEKER
KEGWCVGIGY IIGDKSNKAD FITGKETIPV EALTENGIDE KQIHECLIQR FERPRKTKKK
IYEGPHILIR VITGNQGIPI AYSEKYLTFP FGIIGIHAPQ DDKSELSALY DYLRENNSLL
RSYILATSGR AMIGKATSIN KDDIMRIPYS HNKNDIIFSE AEKIIIEEIA DKRKTEEIAV
LNADITKFAS VFCKTLNSVY QIDNGKFQPY KILNTENYIA IHFEYGKELL TVSEEQVFNL
EQYIQNVIPQ KNIKRPHTHI QKIMKVYGKN TIILIKPKQL RYWLPSIALR DADEVFADYI
KARY
//
