ID   R5KC55_9BACT            Unreviewed;       468 AA.
AC   R5KC55;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Subtilase family exported serine protease {ECO:0000313|EMBL:CCY64315.1};
GN   ORFNames=BN467_01140 {ECO:0000313|EMBL:CCY64315.1};
OS   Prevotella sp. CAG:1124.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=1262920 {ECO:0000313|EMBL:CCY64315.1, ECO:0000313|Proteomes:UP000017956};
RN   [1] {ECO:0000313|EMBL:CCY64315.1, ECO:0000313|Proteomes:UP000017956}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:1124 {ECO:0000313|Proteomes:UP000017956};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCY64315.1}.
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DR   EMBL; CAYO010000023; CCY64315.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5KC55; -.
DR   Proteomes; UP000017956; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR017317; Pept_S8_subtilisin_bacteroid-2.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   PANTHER; PTHR43806:SF7; MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-1 PROTEASE; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PIRSF; PIRSF037903; Subtilisin_rel_GFO_2223; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000017956};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..468
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004395708"
FT   DOMAIN          184..454
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        193
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        230
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        408
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   468 AA;  51062 MW;  6E02E49B9592D189 CRC64;
     MNKLATILVI LFFAVQAGAR PAETAHKVKY PGGKTYMFRV MLKDKHGTPF TLAKPRAYLS
     EKALARRRRQ NIAVDSTDLP VNPAYVKAIR RIGVDVVSQS KWNNTVLVRG TDIRQLRSVD
     ALGCVAGIKL VWTSPDSINK PSYRLKYHKE FNRWDTISQN RYGVTREQVE MIGGVKMHDH
     GFRGRGMTVA VLDGGFMNAD LIPSLKNADV AGWRDFVVPA SSTVFKEMDH GTKVLSTMAV
     DVPYTFVGTS PEATFWLLRC EDNLTESLAE EDFWAAAAEF ADSVGVDIIS SSLGFHAFDN
     PDDNYDYRQL DGHTALISRT ASMLAGKGIV LVNSAGNDGM AAWKKINVPA DATDIITVGA
     VTPERRNAAF SSVGPTADGR VKPDVMALGS PTSVITGRGT IIKDVGTSFS TPLVAGMVAC
     LWQALPGKTA KDIIRLVLDS CDNTAAPDNI YGYGVPDFWR AYERGMKN
//