ID R5R4J3_9FIRM Unreviewed; 470 AA.
AC R5R4J3;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=HTH gntR-type domain-containing protein {ECO:0000259|PROSITE:PS50949};
GN ORFNames=BN526_00409 {ECO:0000313|EMBL:CCZ27967.1};
OS Firmicutes bacterium CAG:194.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1263008 {ECO:0000313|EMBL:CCZ27967.1, ECO:0000313|Proteomes:UP000018384};
RN [1] {ECO:0000313|EMBL:CCZ27967.1, ECO:0000313|Proteomes:UP000018384}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:194 {ECO:0000313|Proteomes:UP000018384};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ27967.1}.
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DR EMBL; CAZT010000026; CCZ27967.1; -; Genomic_DNA.
DR AlphaFoldDB; R5R4J3; -.
DR Proteomes; UP000018384; Unassembled WGS sequence.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000018384};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 14..82
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
SQ SEQUENCE 470 AA; 54686 MW; 542349D0A9542FCD CRC64;
MDNLLIVLDP DNKKHLYEQI YDHIKKEIRE GKLCYGERLP SARLLAQQLQ ISRSTVDLAY
GQLVSEGYLE AKPCQGYFVS HVEELYHIIR ENDDMQKKEQ KEIQKQQTED SFLCDFSPNT
IDMSYFPFST WKRIHRQVLL DEQENVLHKG DPKGDERLRR TIVHYLHASR GVDCSPEQII
IGAGNDYLLL LLQKLFGDVR TVAMENETYL RAYRIFCSNA YRICVTDMDE KGMCASALER
TEADLAYVMP AHQFPTGAVM PVGRRLELLG WAKEKENRYL IEDDYDSEFR YKGKPIPALQ
SLDRREKVIY MGTFSKSIAP AIRVSYLVLP RRLLTLYEQN CSFLSSTVSR IDQAVLNRFI
AEGYFERYLN KMRKVYRQKQ EKMLECLEPF RDRFTIAGEE AGLHILLMPK DKDVTEQMLI
QKARQQGCKV YGLSDYQIIK KETHRVMLGY ASLSLSGIEE GMGLLEKAWL
//
