ID   R5TM91_9FIRM            Unreviewed;       333 AA.
AC   R5TM91;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN   ORFNames=BN683_01517 {ECO:0000313|EMBL:CCZ64449.1};
OS   Roseburia sp. CAG:50.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=1262949 {ECO:0000313|EMBL:CCZ64449.1, ECO:0000313|Proteomes:UP000018378};
RN   [1] {ECO:0000313|EMBL:CCZ64449.1, ECO:0000313|Proteomes:UP000018378}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:50 {ECO:0000313|Proteomes:UP000018378};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the shaker potassium channel beta subunit
CC       family. {ECO:0000256|ARBA:ARBA00006515}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCZ64449.1}.
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DR   EMBL; CBAK010000074; CCZ64449.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5TM91; -.
DR   Proteomes; UP000018378; Unassembled WGS sequence.
DR   CDD; cd19089; AKR_AKR14A1_2; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR005399; K_chnl_volt-dep_bsu_KCNAB-rel.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43150; HYPERKINETIC, ISOFORM M; 1.
DR   PANTHER; PTHR43150:SF4; L-GLYCERALDEHYDE 3-PHOSPHATE REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018378}.
FT   DOMAIN          27..327
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
SQ   SEQUENCE   333 AA;  37639 MW;  387FE83C497D6C79 CRC64;
     MYQAKETRYD KMVYNRCGNS GLKLPEVSLG FWHNFGDTGV YENMRQMVFT AFDNGITHFD
     LANNYGPEYG SAEANLGKLL KENFTAYRDE LIISTKAGYD MWKGPYGDWG SRKYLLASLD
     QSLERLGLEY VDIFYHHRMD PNTPLEETMG ALDQAVKSGK ALYAGISNYD GETMKRAAAI
     MRELHCPFVI NQNRYSIFDR TIEQNGLKQA AQEEGKGIIA FSPLAQGMLT DRYLNGIPAD
     SRVNTDGRFL KKEQLTDSKI HQIQALNEIA KQRGESLAQM ALKWVLKDEV VTSVLIGASR
     PQQILDNIKV IESAGFTEEE LRLIDEVSVE KKA
//