ID R5WDW5_9FIRM Unreviewed; 347 AA.
AC R5WDW5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Phosphopantetheine adenylyltransferase {ECO:0000256|ARBA:ARBA00013868};
DE EC=2.7.7.3 {ECO:0000256|ARBA:ARBA00012392};
GN ORFNames=BN751_00738 {ECO:0000313|EMBL:CCZ93961.1};
OS Coprococcus eutactus CAG:665.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Coprococcus.
OX NCBI_TaxID=1263071 {ECO:0000313|EMBL:CCZ93961.1, ECO:0000313|Proteomes:UP000017949};
RN [1] {ECO:0000313|EMBL:CCZ93961.1, ECO:0000313|Proteomes:UP000017949}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:665 {ECO:0000313|Proteomes:UP000017949};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA +
CC diphosphate; Xref=Rhea:RHEA:19801, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57328,
CC ChEBI:CHEBI:61723; EC=2.7.7.3;
CC Evidence={ECO:0000256|ARBA:ARBA00029346};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCZ93961.1}.
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DR EMBL; CBAW010000164; CCZ93961.1; -; Genomic_DNA.
DR AlphaFoldDB; R5WDW5; -.
DR Proteomes; UP000017949; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004595; F:pantetheine-phosphate adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR038727; NadR/Ttd14_AAA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001980; PPAT.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR PANTHER; PTHR37512:SF1; AAA_28 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37512; TRIFUNCTIONAL NAD BIOSYNTHESIS/REGULATOR PROTEIN NADR; 1.
DR Pfam; PF13521; AAA_28; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR PRINTS; PR01020; LPSBIOSNTHSS.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Coenzyme A biosynthesis {ECO:0000256|ARBA:ARBA00022993};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotidyltransferase {ECO:0000313|EMBL:CCZ93961.1};
KW Transferase {ECO:0000313|EMBL:CCZ93961.1}.
FT DOMAIN 8..144
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT DOMAIN 164..326
FT /note="NadR/Ttd14 AAA"
FT /evidence="ECO:0000259|Pfam:PF13521"
SQ SEQUENCE 347 AA; 40401 MW; 453CEDC4F3AFED56 CRC64;
MYRYKVGMYG GSFDPLHIGH IHDIIRAAAM CEELYVMISW CEGRESTSKE LRYRWILNST
RHLPNVKIIM IEDKAVSKEE YNTDYYWEKG AQDIKDTIAK PIDAVFCGSD YLGTGRFESL
YCPESEIVYF DRAEVPVSST EIREWATAHW EYIPEVCRDH YVRKVLVVGG ESTGKSTLVE
NLALAYNTNF VREIGRDTCE YAGGEEFMVE DDLVENFIRQ KDEVRRAARY SNRLLFVDTD
ALTTGFYCDL LMDDDEQKRR LTDMADAINA TNEWDLVLFL DPDGTDFVQD GTRNEDIMRE
RRHYSDLLKA WFDRHGVHCE TISGDYLCRF NIAKKLIEER LAITTVF
//
