ID R5YMW2_9FIRM Unreviewed; 1193 AA.
AC R5YMW2;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Squalene cyclase {ECO:0000313|EMBL:CDA28783.1};
GN ORFNames=BN504_00327 {ECO:0000313|EMBL:CDA28783.1};
OS Eubacterium sp. CAG:156.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC Eubacterium.
OX NCBI_TaxID=1262880 {ECO:0000313|EMBL:CDA28783.1, ECO:0000313|Proteomes:UP000018124};
RN [1] {ECO:0000313|EMBL:CDA28783.1, ECO:0000313|Proteomes:UP000018124}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:156 {ECO:0000313|Proteomes:UP000018124};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA28783.1}.
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DR EMBL; CBBN010000056; CDA28783.1; -; Genomic_DNA.
DR AlphaFoldDB; R5YMW2; -.
DR STRING; 1262880.BN504_00327; -.
DR Proteomes; UP000018124; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR CDD; cd00688; ISOPREN_C2_like; 1.
DR CDD; cd00198; vWFA; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.4270; Listeria-Bacteroides repeat domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR044060; Bacterial_rp_domain.
DR InterPro; IPR042229; Listeria/Bacterioides_rpt_sf.
DR InterPro; IPR001330; PFTB_repeat.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF18998; Flg_new_2; 1.
DR Pfam; PF00432; Prenyltrans; 1.
DR Pfam; PF07678; TED_complement; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018124};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1167..1186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 552..725
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1053..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1061..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1193 AA; 134028 MW; B5276BEF711C1218 CRC64;
MKSRLLKGIS CLLACVMLLE ATLLYFTKDV YSNENVIALK KEAVKWIEDS QNEDGSWGKS
LGIYNTAEVL KYTGKQNLSG DVREKAVKYL DTAYENNNDD LYRKNSINEI TTEDKIKEII
KMQNNDGSFS VSDEYKGDIF DTLLALEAML SSELMNKKSM EKAVLFVLSN QKEDGSFSYT
GKKDGGVYIT AYAAFILKKY ISENGGKESE KLALNRANEY LVSKENEIIG NDEESLMNLL
MITIALTEID ANRTLQRIEK AGKEIKQDGS LNQDECLTAM FVYAIDEYLT FVRDESVISG
PQITGIAINS DENITAYTDI KVVPEIIGIN DEKHEVSVCM GNESTAYVKG TETDDGYVIN
TKNMEPGEYY IVTMVTDKES GQVLAIKRKQ VEISEGIKIF KSVLNYSPKS VSVNTKKEIK
FKLRAETGIN TNTDIDININ VENQNGENVY EDNRNIDADA NTKYIECNDF SFMSQADTDD
LYTVTVRYKN KNTVIKTDRA LIKVFDEENE NRIDIKYEAD KDEITDDDKY VNVKFDMQGI
GLSENIKRRP MDIVIILDNS GSMRTEDWKN AEEGAKIIVN YMQPEDRALI RYVNRGNAET
GFSNDKEYLN EVLSRGVWLW GGTPIYSSIN NSINDLKNSE YRDKVIYLFS DGERWGDSPE
INVKELKDLN ITIYSVFLEA NASEESRVEA KKTMQYIADI SDGVALSAPT NDEIAECVAK
LANDIFMVAG KNIELKMKLN KDINPDDIEF SNAPDEIIKN DDGTNTLLFK QGYLSVGQDN
NMEMKVPVTG IADDEIINLM DEITLSYTNE NDEKVELKLD PLTVKRKITT EIVETEPETK
QSTEEAVDKK GIYAKNVIPK ESDEQGKAIK GNVSVDNTDM ETGDTAKISY VIENKGQEKE
NGILKISAIN IKNKNVTELE NKEVEIGQGE KITETIDTDT SLLGEGNFLI IYQFVTDDEV
ILMDEAGFKL TDHAYNFKIQ CSDGGSVVSK FMETYKEGQT ISLKAKADDG YIFAGWECDY
GAFSDRYDKS TMFTMPGNDV TVKAVFAKKK NMENHDNSIS ESVTKDNSGE KPGNEITTQK
AVKKDGNSNV KGRSEKSEKN SASTKEKHEK NANISGKHKK EYGKNDSIKK NSDGIKTYNV
DENNQNNKEI KSGSPVKTGD FETRKTIAAL MIIQFISIIV IIFMAGKKEK EEQ
//
