ID   R5YW85_9FIRM            Unreviewed;       661 AA.
AC   R5YW85;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Penicillin-binding protein transpeptidase domain protein {ECO:0000313|EMBL:CDA28834.1};
GN   ORFNames=BN504_00378 {ECO:0000313|EMBL:CDA28834.1};
OS   Eubacterium sp. CAG:156.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Eubacteriaceae;
OC   Eubacterium.
OX   NCBI_TaxID=1262880 {ECO:0000313|EMBL:CDA28834.1, ECO:0000313|Proteomes:UP000018124};
RN   [1] {ECO:0000313|EMBL:CDA28834.1, ECO:0000313|Proteomes:UP000018124}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:156 {ECO:0000313|Proteomes:UP000018124};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA28834.1}.
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DR   EMBL; CBBN010000057; CDA28834.1; -; Genomic_DNA.
DR   AlphaFoldDB; R5YW85; -.
DR   STRING; 1262880.BN504_00378; -.
DR   Proteomes; UP000018124; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018124};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          73..235
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          276..596
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   REGION          616..661
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        616..630
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        631..661
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   661 AA;  74129 MW;  3837327E5AB5D730 CRC64;
     MVENRRRPAR RSYKRAEFNK GMQKKLAIVF VLIILALFAL CIRIGYLTKA KGDEYSIKVL
     AQQGYTSKTL PYKRGDILDR NGNVLATSVK VYNLVIDSKV ILSNKKYLEP TVNVLTRYFD
     LNKDELTKGI KERKDNSYWV VLKQLEYKDI EGYKDYINKE DPSKEEAKEI SYVKGVWFEE
     EYKRMYPYNS LACSTLGFVN KDGSANIGIE SSYNDVLSGL NGREYGYVNS DNSMETVIKD
     PTNGDTVVST IDMNIQRIVQ KAIKKYMKKY QPKRLAAVIA DPNTGEILAM ADNTTFNLNE
     PWDLSFKYTE QEQENLSEKE ISDALNSRWK NFCVSDSFEP GSTIKPFTIA AAYEEGKTTR
     NSTYFCDGYE VVGGFTIRCH DVSGHGTITT KQALAYSCND ALMRIGFDLG AKKLVEYQRR
     FGFGAKTGID LPSETRGLVY DSNMGASSLA TNSFGQNINV NMIQMVAGFS SLVNGGNYYE
     PHVVKEVVSE DGELIDNYSK TLVKETVTDK TSDFIKEALR AVVTDGTGKT AAIPGYTIGG
     KTGTAEKHYT DGKTGRIPGE YIVSFLGCAP VENPEVVCYT IMDSPKEDTQ STAFSTEFWT
     YIMKQVLPYM GVSQTEDAGK DKDITNTKKS DIKDNYSQGI TQEDMPVETQ TENQNDYTGE
     E
//