ID   R5ZTI6_9BACT            Unreviewed;      1881 AA.
AC   R5ZTI6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Alpha-2-macroglobulin family protein {ECO:0000313|EMBL:CDA42743.1};
GN   ORFNames=BN693_00963 {ECO:0000313|EMBL:CDA42743.1};
OS   Prevotella sp. CAG:5226.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=1262930 {ECO:0000313|EMBL:CDA42743.1, ECO:0000313|Proteomes:UP000018184};
RN   [1] {ECO:0000313|EMBL:CDA42743.1, ECO:0000313|Proteomes:UP000018184}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:5226 {ECO:0000313|Proteomes:UP000018184};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA42743.1}.
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DR   EMBL; CBBW010000065; CDA42743.1; -; Genomic_DNA.
DR   Proteomes; UP000018184; Unassembled WGS sequence.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF01835; MG2; 1.
DR   SMART; SM01360; A2M; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018184}.
FT   DOMAIN          1132..1222
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   REGION          1102..1123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1881 AA;  207480 MW;  B6CFD420AB804BB9 CRC64;
     MNKMTTLIAA FGISMGAPAQ SYDKLWQEAK AHVDNDLPKS AIEVVNKIQQ KAVAEGNDAQ
     LLRVMLTQRM LGAELSADSV APWLQRMEAA LAAETKPAMQ ALWHVALAKC YEGTSYGQVL
     VIDGNTLTYD ALQQRATTHY EASLTNLDAL ADARVDNYLP LFTKHEGSVC YHNDLLHVVL
     NDYCESGVTK QGDKQAWTEK IAAFYKARHA NDAALLLSLR ALEQRYENAS VKGRIEHNAY
     YKALCQLTDE YAGAGSCVKI YEAMVALQAN YVQDDGPYAA HNDSVLVAQA EKGISLSKKG
     NAANELRNFV ARMTAPAVYA DGLQRVCYPG SQLTLAFRTR HLREVELRVT RLPKSAAELH
     AADNDVLKAL AKKAGSGACT ITRLQLTGQT APYAWRTDSV RFEVPNVPGV YYVELVGDGR
     VLERSTMAVS SLSAVRFATP GGKTRITMVD SQTGRPVTGV QLTAYRYDNS SRKLRQIRTY
     ATDAEGNVSL QTDVNRYDAT LYAATTATDA ASPLFNINDI RYYDTQRQWA ETRVQLYTDR
     AIYRPGQKVA FSAVAFTREG DVHRVRPALQ LKATLRNANG KVVDTLLVQT DAFGTASGEF
     NLPQACLPGR FSISVDSRSV SGRNYFRVEA YKRPTFTATT QPVKAAYALG DSVTVEGEAK
     TYSGVAVADA RVQYTVRRTA WFFYNDDEMA PQSGETTTDA EGRFKLPVLL ESPENEADAA
     LPRYNRYAYV VDYTVTAPNG ETAQGSATLN VATRKAWLEV SAPQTIYRRQ GAALPTFGIR
     QLNAQGENMA AKGTFVLRKG GEEVARGVFD TNEPLAISQL AQLPSAQYTL SVQTAEAAAD
     TVTFTLLRDT DTTPVVANQP FFFYKETAND GAAARIVVGS TEKDACLFYD VVAGNRVVES
     RRIMLNNELL HLTFDYKEAY GDGAVLCLAM VRHGQLYEES VSVEKPKPDK RLLLRWTSFR
     SRLTPGQQEE WRVQITRPDG TPADAQMMAC LYDASLDALV KNTWAEYAVN FYRYLPSPLW
     QTNRTVHGLA LYGVYDYKRL SVPDVQYSRW RNDLFNYERV YELAGIRPRR MRTMAALEVD
     KPMMMLAKAN VATDMYDAGA AESASSNQKK EAAGGAPQPL QTAAPRTNFA ETAYFRPALR
     TNSKGEVVMA FTLPESMTQW NFAALAHDRD MNHGRLDTTV VARKDFMVEP ALPRFLRQGD
     TTDLPVKVTN LSGKAVSATL TLTLGDAVNG QQYHKADAKV MLAPGESRVY TFPYQAKGNE
     GVMVCRAMAQ GKGFADGEEH YLPVLTNEVQ VTRTLPFSQT KAGVLTLRTD TLFNVEGASH
     RALSVEVSSN PTWYAVTALP ALQGTDGCIS ANDWATRFYA MAIGQQVARD NPEIKALASG
     SSTAELDALA KLKAEGLTDL TPWLQQGAAE QERAEALRQM FDVELTAARM ATAIDKLKTL
     QQADGAYSWY PGMGGNAYTT LEVAILLARV ENLTSCQQGH RQLAQAMDWL KQYIAGVVRE
     MKRAEKETGH KVLPGELAMR YLYLLTLTGD KLDDNASYLV ARAALQNKEF TMYGKAVAVQ
     VMAHYGKKAE AELLLKSLLE HTVTKDSMGR WFDTPRAEWS WRSYRIPTQC MAIEALHTLG
     HEMAADEMRL WLLQAKRTQM WETSRASADA VYALLATGGK QQGVMPLVEK TPVYYTLYNH
     NKVVGFNAKS QSSMPQTVGY FKQTYTDASA TGATTVRLDK RTDGLSWGSV YATFSAPASR
     VSTEGKGLLL TRKFEVKRGG EWVAVNGTTT LVKGDRVRQV FTITADRDYD FVALSASRPA
     CLQPAQPLSG YAWNMALPAY RAVHDAATDY FVEKVRKGTH QFAEELFVDR TGQFATGVAT
     VSCVYAPEFC GTAGEVKLIT H
//