ID   R6A0F1_9BACT            Unreviewed;      1151 AA.
AC   R6A0F1;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   ORFNames=BN693_00676 {ECO:0000313|EMBL:CDA42204.1};
OS   Prevotella sp. CAG:5226.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC   Prevotella.
OX   NCBI_TaxID=1262930 {ECO:0000313|EMBL:CDA42204.1, ECO:0000313|Proteomes:UP000018184};
RN   [1] {ECO:0000313|EMBL:CDA42204.1, ECO:0000313|Proteomes:UP000018184}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:5226 {ECO:0000313|Proteomes:UP000018184};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA42204.1}.
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DR   EMBL; CBBW010000026; CDA42204.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6A0F1; -.
DR   Proteomes; UP000018184; Unassembled WGS sequence.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.80.10.50; -; 1.
DR   Gene3D; 1.20.1270.90; AF1782-like; 1.
DR   InterPro; IPR035992; Ricin_B-like_lectins.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018184};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..1151
FT                   /note="exo-alpha-sialidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004411926"
FT   DOMAIN          585..868
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   1151 AA;  123617 MW;  2A30F02CD0911D33 CRC64;
     MKRNYFNGLL AALTLFGLGT SQAWADKIVT STAENPKWFR IYTPNRSNLS LISKGVGVAM
     QNTKTFEKPY SASQLWRLEA GSTDGTYKIV NMSGEYISPS STVKPNNNAA FAPVKSGAGD
     WTITDLSDDT YTITSGSVQF NTSQDGPNYY LYNWGSGTNK EDAGCKYRFE AVSLTELETA
     QAKALSVLNE TEEGTNPGQY PAEVRTTFTN AIKAATTVDA ITAAQTTYSA AMVQVAAGKT
     YYIVSDKSVG YCQGKYIYSA GSEAQPKWGN KVVSAAYGWT FTDAGNGQFY VQNYGTKEYI
     EPNSTDVNGA TKTTATPATK YTVTSLGQGV FNIKPDGKNP LHAQNDGAVL VMWAGGIGSA
     SAWRLIEIPE SDLTATPTFN SINVAPGFQT YAAGNKEQVL LTFQTEVAGF NGNVVGKSLK
     LNLGATNVAG LENIKVFTSK NANFVSNGQR DAALIGQVAT VSGNEVEVAF DNALEMPSGT
     TRFYVTADIT DKAVVGDSVD AALVSFTYGD NKVFTVNNGN PEGIARVYKV QSVPFMPNDL
     GTAFWRIPSM VVLHNQKGAN ASKNGRVVTM ADNRFNHGGD LPSHIDVYER HSDDNGKTWS
     AHKWVVGNET DEALVASKDG KHKGFGDVTM VETASGKIIA LMVGGQGYFY STNEDGNRIV
     PVIITSTDGG DTWSQARALT DELYKGVYEQ GQVLGSFAGS GRGICLQRQK DAKLNGRVMF
     AMSHRFATGA IQEYIIYSDD EGETWKMSPK SAYNGGDESK LVELADGTVM ISVRQNGQRG
     FNTSTDGGMT WGTQTTNADI NGNPCNADIL YYNNKVLLHS YINNGSRKNV TVKASFDNGK
     TWGHPVVICA PSSCYSTMDI TKDGDIAIFY EDNACTQGYA LNYAVFPIDW IVPGGDPSAK
     AFQEALAKAK AATTNEGYTD EATAKAGQYS QEAIDNVKSL IATYEASVTD YEAATAALNA
     AVEAMGKTAC TVDGYYNETT FTISSLSTIS SLEGAGYISA DAKAKSEADN TAEWQIVPAT
     VAGQVYIKLK DADSYIFRSG NTLAASAAPQ AWKLVKNDGF YNLIAVHKAE NSYLVINVGT
     GEFNWWTSAA GDNTWSTKFV LTAKTVVTDI NNATVANGSE KAVRYYDLQG RRVLNPTKGL
     FITNTGKKVI K
//