ID   R6B327_9CLOT            Unreviewed;       919 AA.
AC   R6B327;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=RNA polymerase subunit alpha {ECO:0000313|EMBL:CDA53361.1};
GN   ORFNames=BN491_01513 {ECO:0000313|EMBL:CDA53361.1};
OS   Clostridium sp. CAG:138.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1262775 {ECO:0000313|EMBL:CDA53361.1, ECO:0000313|Proteomes:UP000017905};
RN   [1] {ECO:0000313|EMBL:CDA53361.1, ECO:0000313|Proteomes:UP000017905}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:138 {ECO:0000313|Proteomes:UP000017905};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA53361.1}.
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DR   EMBL; CBBZ010000106; CDA53361.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6B327; -.
DR   STRING; 1262775.BN491_01513; -.
DR   Proteomes; UP000017905; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR   CDD; cd06171; Sigma70_r4; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR011260; RNAP_asu_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03118; RNA_pol_A_CTD; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   SUPFAM; SSF47789; C-terminal domain of RNA polymerase alpha subunit; 2.
DR   SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017905}.
FT   DOMAIN          127..180
FT                   /note="RNA polymerase alpha subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03118"
FT   DOMAIN          337..368
FT                   /note="RNA polymerase sigma-70 region 4"
FT                   /evidence="ECO:0000259|Pfam:PF04545"
SQ   SEQUENCE   919 AA;  104092 MW;  21BC2E489C6B2A6B CRC64;
     MMNRTNKTEI ITKDDIRNTE ATLSDLLNVS PDVCGDDETT VLDLPVRSEK RIAGIGIRYV
     KELLSIKLGR LLAIGGMGLG SLNDIAGAIA KRISEAPGDD GDGSKDIPDA PFTSNAQAEC
     NELGRPVYIE ELGLSVRSYN CLKRSGITVV SDLEKLSRDE LLSIKNLGAS SADEILNVLK
     DFDPKEKLEK RLEAEQEERE RQEECSALAS ELFTAYGCVP SEWSSMIRKC LIKEPGTGIG
     GAVIRLYEQT ELFDHLRNLL LNLVEAHQDK LDVDELTTLL PKHLQGTDLA DKAVDSLKAD
     GAVAIEDGII IRIYPSISDY VKQIEDERMR SVWSLKLEGL TLEQIGERIG GVTRERVRQI
     LNKALKQLPR LREDRYLYMF GNYSFSYEDL NIAFGEPEYV FNYLDLAAGT KAAERRPLSE
     ALEDENIKEE DRRNIERAVF KNSVMLDGVR VEKVRPELVK RFIKSRCKED THIDDLAGSF
     NAAMAELGIT DERLFLPETN TVENHLQIAD YILWKNGRSF RAYDIESKDI DRLWSELDLE
     QYEGLDISAL MLLRSEPELM REFDIRDEYE LHNLLKKTAA GRIRGLSFGR MPMLSVGSAS
     RTEQMRELLV ENAPIEADTL CGLYEELYGM KAEVIKAYYL KEFDRYYHNG LFTFDAVRMP
     PYVLSRMKEL LSNDSYTIAE IKSIFRREFP EESPEEINAY NLKELGFAVY SGYVIVNSYS
     NAREYFRAVL TENEITDLTG EWERFGRFPT FSQEVYALED LRTITEYEPN RFIGIGKLNE
     MGVTKEDLDD FCRSVRDHAG RGEYFTVKSL LGSGFDSPLV HSGLGEYFLS SVLASGEEGF
     PYQRMGGVKL FCSSGERPSL PAFLRSIVRG HGSILIADLE NLLRDEYGIE LPPYKLTELI
     KESGTGYDPI TRTAFDASR
//