ID   R6C9F7_9FIRM            Unreviewed;       988 AA.
AC   R6C9F7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=CoA-substrate-specific enzyme activase {ECO:0000313|EMBL:CDA72245.1};
GN   ORFNames=BN718_01105 {ECO:0000313|EMBL:CDA72245.1};
OS   Ruminococcus sp. CAG:579.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Ruminococcus.
OX   NCBI_TaxID=1262963 {ECO:0000313|EMBL:CDA72245.1, ECO:0000313|Proteomes:UP000018387};
RN   [1] {ECO:0000313|EMBL:CDA72245.1, ECO:0000313|Proteomes:UP000018387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:579 {ECO:0000313|Proteomes:UP000018387};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDA72245.1}.
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DR   EMBL; CBCK010000054; CDA72245.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6C9F7; -.
DR   STRING; 1262963.BN718_01105; -.
DR   Proteomes; UP000018387; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.40; -; 4.
DR   InterPro; IPR002731; ATPase_BadF.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018709; CoA_activase_DUF2229.
DR   InterPro; IPR008275; CoA_E_activase_dom.
DR   NCBIfam; TIGR00241; CoA_E_activ; 2.
DR   PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR   PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR   Pfam; PF01869; BcrAD_BadFG; 2.
DR   Pfam; PF09989; DUF2229; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023014};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018387}.
FT   DOMAIN          7..230
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          320..574
FT                   /note="ATPase BadF/BadG/BcrA/BcrD type"
FT                   /evidence="ECO:0000259|Pfam:PF01869"
FT   DOMAIN          670..886
FT                   /note="DUF2229"
FT                   /evidence="ECO:0000259|Pfam:PF09989"
SQ   SEQUENCE   988 AA;  108115 MW;  B7D37DE53C613C87 CRC64;
     MSIIYDLGID VGSTTVKTVI LKEGEIIYSK YERHFSKVRE TVAEQLRIIN EKYKGERFRT
     AITGSAGLGI AQASGIEFVQ EVYSAFVAVN KSYPLTDVVV ELGGEDAKII FLTGGVEQRM
     NGSCAGGTGA FIDQMAQLLG VTADELDRLS LKSTRLYPIA SRCGVFAKSD IQPLLNQGAK
     KEDIAASIFQ AVVDQTVSGL AQGRKIAGNV LFLGGPLSFL KGLRKAFTET LHLDAEHAVF
     PDLAPCFMAY GCALQAHDIS EAMTIDETLD KIINAKTADN IVTGTPLFKD RAEYEEFVAR
     HKQSDLKYAD IKTYSGDAYL GIDAGSTTTK LVLITPDGRL LYQHYCSSKG QPLDIIASKL
     EDIYRIANPG LNIKASAVTG YGEDLIKAGL GVDFGIVETV AHYKAAAFFC PDVDFIIDIG
     GQDIKCFKIK NNAIDSIMLN EACSSGCGSF IQTFAQAMGY EIADFANLGL FAKAPVELGS
     RCTVFMNSSV KQAQKDGASV EDISAGLSSS IIKNAVYKVI RAKSIDELGK NIVVQGGTFL
     NDAVLRSFEM ELGRNVIRPA IAGLMGAFGC AIFAMEKTKA EPQRTSSILT LDQLRDFAYN
     SMSAQCGGCT AHCNLTIIRF SDGHRFVSGN RCEKGAGIKL ANKTENMYEY KLEQLEAYGE
     KKPHGKPIAR VGIPMALSYY DMLPFFHTML TELGFEVVLS DESSRDTYYR GQQTIPSDTV
     CYPAKLAHGH ILNLLDKGVD FIFYPCMSYN IDEGQADNHY NCPVVAYYPE LLKANIPDLN
     SSNFITPYLD INFKKNTAKN VAAALRSYGI KEKQVLGVLN KAYSEQLRYK RANEQKALEI
     IADARSKGQK IIVLAGRPYH IDREINHGIH KLIASLGFAV VTEDSVANLV DCPPLDVLNQ
     WTYHARLYRA AEYVCENDDM QLVQLVSFGC GIDAVTTDEV RAILEEHGKL YTQLKIDEIT
     NLGAAKIRLR SLAAALEEKD AAKNGKEV
//