ID R6DS20_9FIRM Unreviewed; 1018 AA.
AC R6DS20;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00013303, ECO:0000256|RuleBase:RU361154};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|RuleBase:RU361154};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230, ECO:0000256|RuleBase:RU361154};
GN ORFNames=BN710_01135 {ECO:0000313|EMBL:CDA91248.1};
OS Ruminococcus sp. CAG:563.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1262961 {ECO:0000313|EMBL:CDA91248.1, ECO:0000313|Proteomes:UP000018082};
RN [1] {ECO:0000313|EMBL:CDA91248.1, ECO:0000313|Proteomes:UP000018082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:563 {ECO:0000313|Proteomes:UP000018082};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412,
CC ECO:0000256|RuleBase:RU361154};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDA91248.1}.
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DR EMBL; CBCR010000085; CDA91248.1; -; Genomic_DNA.
DR AlphaFoldDB; R6DS20; -.
DR STRING; 1262961.BN710_01135; -.
DR Proteomes; UP000018082; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023001};
KW Cellulose degradation {ECO:0000256|ARBA:ARBA00023001};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023001};
KW Reference proteome {ECO:0000313|Proteomes:UP000018082}.
FT DOMAIN 736..1006
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1018 AA; 117129 MW; 0CD5F940B4D141E0 CRC64;
MLNIPKYYED PTTLHVGCEE PHAYFIPYLN EDNALTKPRE DSKYFQLLNG EWDFRFYNSI
IDVEDGFYAA DYELNGNYDK IRVPMNWQMA LDKGYDVPNY TNSDYPYPCD PPYVPDDDPC
GIYIRNFEID ENDLGRDLFL NFEGVDSCFY LWINGKFVGY SQVSHMTSEF NINEFVHAGS
NRIAMLILKW CDGSYLEDQD MWRMSGIFRD VYILKRSRRG RIRDFYVTTE LKKKYTKCIM
SIDLDLVGDR EVSYRLVSPH GENIDSGESV NGKIKIKFDN PILWSDEDPL LYDLFLDVSD
EVVLVKVGIK DLVISKSVLY LNGQKIKIKG VNRHDSHPLY GHATPIEHVL EDLYIFKRHN
VNAVRTSHYP NDPRFLEMCD QLGLLVIDES DLEAHGFSTS IDGFHFERWS LLADDPAWKE
AYVDRARRLF ERDKNHVSVI FWSLGNESGC GDNHQAMYDF IKSRNKNVIV HYENANYRYS
ELAGKFLGNC SDVESWMYPS IEKCREILSS KKRKNKPLYL CEYCHAMGNG PGDLGDYWEL
IDSDDKFCGG CIWEYTDHSV AIPDGSGKYK YTYGGDFGDM PNAGNFCVDG LVYPDRTPHT
GFEEAKYVYQ PFFAEYAGNG NVSIKNRNFF KGLDDVGINW EIKSNGKLIA SGEVSGLMLM
PREKKDFSIF DPSAYSFTGE TYLTLHFVNR TDKLWAKAGY EIGLKQFKLK SIPTGKAALP
TTAMTVNDGE RYVEIGIGSV KYVFDKAYGK LNKISCDDTE LISKPVEINL YRAYIDNDSQ
YYREKWYKVG MEKLGQKCRS LNVTKSDDKV EITVDLAIGV YTFEPIFEGK VTYTFLPDSS
VLVNVNGKKA ERMDILPRIG LQLIMPEGFE SYEYFGYGPK ESYIDKKRYT YVDDFTTTVT
DNFEHYVRPQ ENSSHYDCKW AKVTNESGIG FICRAEDFDS FSSNAQHFTP QMIREAKHDY
ELEPMKETVF SIDYKMTGTG SGACGPDIDP KYSVNDKTFN FTFKILPTNT NGVDPFTV
//
