ID R6IX51_9FIRM Unreviewed; 1000 AA.
AC R6IX51;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00013303, ECO:0000256|RuleBase:RU361154};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756, ECO:0000256|RuleBase:RU361154};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230, ECO:0000256|RuleBase:RU361154};
GN ORFNames=BN517_00767 {ECO:0000313|EMBL:CDB42542.1};
OS Ruminococcus sp. CAG:177.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Ruminococcus.
OX NCBI_TaxID=1262952 {ECO:0000313|EMBL:CDB42542.1, ECO:0000313|Proteomes:UP000018315};
RN [1] {ECO:0000313|EMBL:CDB42542.1, ECO:0000313|Proteomes:UP000018315}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:177 {ECO:0000313|Proteomes:UP000018315};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412,
CC ECO:0000256|RuleBase:RU361154};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB42542.1}.
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DR EMBL; CBDQ010000127; CDB42542.1; -; Genomic_DNA.
DR AlphaFoldDB; R6IX51; -.
DR STRING; 1262952.BN517_00767; -.
DR Proteomes; UP000018315; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023001};
KW Cellulose degradation {ECO:0000256|ARBA:ARBA00023001};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023001};
KW Reference proteome {ECO:0000313|Proteomes:UP000018315}.
FT DOMAIN 718..997
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1000 AA; 113905 MW; 00C1BDA6B3B96617 CRC64;
MEYKLNTTNY RDFKVIEDNK LAGRAYFIPY SKKEKLCAVD LKHERTDSDL VEVLSGEWDF
KYYNDISLIP EVFDAAGVEF DRIHVPSTWQ RTGYEPPVYL NCPYEFDLPN PNVPEHMSAG
IYRKTFEVTN SDDVHILSFL GVVPCVDLYV NGMYVGYSEG AHNSAEFDIS EFIYEGTNEL
LAVVHKWCSG TYLECQDMFR ENGIFRDVLL YRLPAVYIND YYIRPRKADG KWTMDVEITL
EGKLNGCEVA LSLEKDGKII AGEAVKAERL TYMTFDNLDV TEWNAEIPTV YSAYITLYKN
GEELMTLRNI TGFKTVEIKG NTFTFNGQVI KFKGVNHHDT NGKTGYVMTF DDYEKDVKLI
KEYNGNAIRT SHYPPDPCLI ALADTYGLYI VDEADIETHG AFFAPHNDIN KISHDLKWAP
RYLDRVKRMY YRDRSHPCIT MWSLGNEAGG YACQDVCYDY LHETCPEIPT HYEGVIHTKR
KAYDVVSDMY PTHAQVEHVG MGTQRGKWYK TKPYFLCEYV HAMGFGPGAM EEYWDSFYKY
DNLMGGCIWE WADHAVYHAD GPYEYTYGGD HGEKKHDGNF CVDGLVHPDR TPSSGALEMQ
AVYRPVRAKY NRDGSFTFTN TNRFRSSGYI TIVRSMTVDG IEGKERERFS LDIAPCKSEK
VTFKTKIPAG CDCRMNFEYF DGGAFLAREQ VIIKKEHKKV ALPTGSKFEC KVGRNSAKVS
FDGGSVKFDL KTGEIASYKL GEKELINQSP AAHKGFIPNI FRAMLDNDRV IIEKWEKAGY
DDIKAIPHSV NFSSAKHSAK FTVDFNLRSK KGVVAKVNLK YTVDAAGCIK VETVFNSKSQ
QRAAAALPRF GLMFEMPMSF ENIEYLGYGP SENMIDFREH TTFGTYKTTV NDMDEFYIKP
QDYGVRTGVR KLSITDADGV GLMICNPDRD LSFTARHFTQ ALMQRSMHRD DLHSENTTAI
DIDGFLRGTG TGSCGPDVLP QYTVDGRKEL AYSFVIVPIK
//
