ID   R6J8W4_9BACT            Unreviewed;       538 AA.
AC   R6J8W4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Alpha-L-fucosidase {ECO:0000313|EMBL:CDB55069.1};
GN   ORFNames=BN502_01385 {ECO:0000313|EMBL:CDB55069.1};
OS   Akkermansia muciniphila CAG:154.
OC   Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC   Akkermansiaceae; Akkermansia.
OX   NCBI_TaxID=1263034 {ECO:0000313|EMBL:CDB55069.1, ECO:0000313|Proteomes:UP000018106};
RN   [1] {ECO:0000313|EMBL:CDB55069.1, ECO:0000313|Proteomes:UP000018106}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:154 {ECO:0000313|Proteomes:UP000018106};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-
CC       1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the
CC       carbohydrate moieties of glycoproteins.
CC       {ECO:0000256|ARBA:ARBA00004071}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDB55069.1}.
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DR   EMBL; CBDW010000055; CDB55069.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6J8W4; -.
DR   Proteomes; UP000018106; Unassembled WGS sequence.
DR   GO; GO:0004560; F:alpha-L-fucosidase activity; IEA:InterPro.
DR   GO; GO:0006004; P:fucose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR016286; FUC_metazoa-typ.
DR   InterPro; IPR000933; Glyco_hydro_29.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10030; ALPHA-L-FUCOSIDASE; 1.
DR   PANTHER; PTHR10030:SF46; ALPHA-L-FUCOSIDASE-RELATED; 1.
DR   Pfam; PF01120; Alpha_L_fucos; 1.
DR   PRINTS; PR00741; GLHYDRLASE29.
DR   SMART; SM00812; Alpha_L_fucos; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..538
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004410143"
SQ   SEQUENCE   538 AA;  59423 MW;  716E830D2DF16916 CRC64;
     MNIATISALA VTLGLPAPAQ QSATKIITEN GQPALALDEQ FAARLRDGGM KQGFPATVPA
     EFSAAAPGLP LPADANHAAV RETAEERNRR MEWWRDAKFG MFIHYGLYSG LAGEWKGRPG
     GSEWIQKNVE VDTDTYAAEA LPLFKPREGL TEEWAQLARD AGCQYIVLTS KHHEGFGLFD
     SALTDYDAKS AVNRDIIREY VDSCRRRGLK VGLYHSVIDW HHPSYDNTIC PDLCYPAGQA
     AMLNRKNIPR DHAAYQKYLH AQVRELMTRY APIDIMWWDY SQGAMEGAKG WKAPELMDMV
     RSINPGVIMN NRLYAYSGLN KDQAGTLDLR CGDYITPERF IPRRGYPGVD WESCMTVSDK
     WGYNRYDTNI KSPETIIEKL VECVTKGGNL LLNVNPMADG TIPEKVAATM RGVGRWLNIN
     GEAVYGTRAF IQLDQPASIN RQGDIFVFLI PPPDKGAAQP PSEGTMKELT AGAEHARMQP
     LDATGYEDDE GTAITLPAGY SKALLLGDNA VLPVVNGTVL FKAHEHSKTP CSVIKLSK
//