ID R6KD06_9BACE Unreviewed; 997 AA.
AC R6KD06;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=D-lactate dehydrogenase (cytochrome) {ECO:0000256|ARBA:ARBA00038897};
DE EC=1.1.2.4 {ECO:0000256|ARBA:ARBA00038897};
GN ORFNames=BN506_02660 {ECO:0000313|EMBL:CDB71375.1};
OS Bacteroides cellulosilyticus CAG:158.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1263038 {ECO:0000313|EMBL:CDB71375.1, ECO:0000313|Proteomes:UP000018191};
RN [1] {ECO:0000313|EMBL:CDB71375.1, ECO:0000313|Proteomes:UP000018191}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:158 {ECO:0000313|Proteomes:UP000018191};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the FAD-binding oxidoreductase/transferase type
CC 4 family. {ECO:0000256|ARBA:ARBA00008000}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDB71375.1}.
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DR EMBL; CBEB010000207; CDB71375.1; -; Genomic_DNA.
DR AlphaFoldDB; R6KD06; -.
DR Proteomes; UP000018191; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.30.70.2740; -; 1.
DR Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR InterPro; IPR004017; Cys_rich_dom.
DR InterPro; IPR004113; FAD-bd_oxidored_4_C.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR016164; FAD-linked_Oxase-like_C.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR016171; Vanillyl_alc_oxidase_C-sub2.
DR PANTHER; PTHR11748; D-LACTATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11748:SF111; D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02754; CCG; 2.
DR Pfam; PF02913; FAD-oxidase_C; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF13534; Fer4_17; 1.
DR SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF55103; FAD-linked oxidases, C-terminal domain; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 3: Inferred from homology;
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Reference proteome {ECO:0000313|Proteomes:UP000018191}.
FT DOMAIN 39..267
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 997 AA; 110516 MW; A0315CC711753115 CRC64;
MVKSSYTSFL QEIRGLIPQD RIYTDELRRL AWGTDAGFYR LIPQIVIRSN SEEEISDLLR
LADRYGLPVT FRAAGTSLSG QAISDSILIV AGKHWEKYSI SPDHEQITLQ PGIIGQRVNE
ILAPYGRKFA PDPASVKSAM VGGIVMNNAS GMNCGTHANS DKVLLSARIV LADGTMLDTG
DDISRASFEA THPDFYNRIC ELRDQIRANE ELAARIRYKY SIKNVTGLNL LPFIRFDDPF
DIIAHLMVGS EGTLAFLSQI TMRTEYDYPH KASAMLYFTS IKDACRAVVA MKELTNRNSS
SPSSVSSADE KLVKGAELLD YKSLSSVEDP IYLKYKQEVA DASGLTAVLT ETKARTREEL
EQNISVIEEC LKPFSTYIPV HFTDRPEEYS KYWAIRSGIF PSVGGTRQPG TTCLIEDVAF
HIEDLPEATA DLQQLIARHG YDDACIYGHA LEGNYHFILN QSFSTDADVK RYEDLMNDVK
TLVVDKYDGS LKAEHGTGRN MAPFVKYEWG EAAFEAMKAV KQLFDPKGLL NPGVIFNDDP
QCHIKNFKPL PLIPIDEASP AEKVNKCIEC GFCEVNCLSC GFTLSSRQRI VLQREISRLK
QSGTDPERLS LLEKQYRYPG NQTCAGDGLC SMSCPMNINT GDLTHIIRQE TLPKGSLGYK
AGDFVANHFA GVKSSLRPVL SLANFGHSVL GTKAMSSITK GMHNVLGIPL WTPAMPKSYK
VTSYKLQATT DMSDELQATS TMQNDSATLV ACSSVARNST ADKVVYFPSC INQTMGLPKK
SPVEQPLVNK MISLLQKGGY EVIFPKDMDK LCCGTIWESK GMLDIADRKA AELEAALWEA
SEQGKYPVLC DQSPCLHRMR ETIQKMKLYE PAEFIYTFLR DKLVFTQTDR PVAVHITCSM
RKMGLADTIV SLAKLCSTHV FVPEEVGCCG FAGDRGFTYP ELNSYALRKL RPQIEASGIT
IGYSNSRTCE IGLTTNSGIP YVSIAYLVDQ CTKGIDN
//
