ID R6P1U4_9BIFI Unreviewed; 2300 AA.
AC R6P1U4;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN ORFNames=BN571_01066 {ECO:0000313|EMBL:CDC14654.1};
OS Bifidobacterium pseudocatenulatum CAG:263.
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=1263060 {ECO:0000313|EMBL:CDC14654.1, ECO:0000313|Proteomes:UP000018036};
RN [1] {ECO:0000313|EMBL:CDC14654.1, ECO:0000313|Proteomes:UP000018036}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:263 {ECO:0000313|Proteomes:UP000018036};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC14654.1}.
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DR EMBL; CBEV010000022; CDC14654.1; -; Genomic_DNA.
DR Proteomes; UP000018036; Unassembled WGS sequence.
DR GO; GO:0005835; C:fatty acid synthase complex; IEA:InterPro.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004318; F:enoyl-[acyl-carrier-protein] reductase (NADH) activity; IEA:InterPro.
DR GO; GO:0004312; F:fatty acid synthase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00828; elong_cond_enzymes; 1.
DR CDD; cd03447; FAS_MaoC; 1.
DR Gene3D; 3.30.70.2430; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.90.25.70; -; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013565; Fas1/AflB-like_central.
DR InterPro; IPR047224; FAS_alpha_su_C.
DR InterPro; IPR003965; Fatty_acid_synthase.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR10982:SF23; FATTY ACID SYNTHASE SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10982; MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF18094; DNA_pol_B_N; 1.
DR Pfam; PF08354; Fas1-AflB-like_hel; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR01483; FASYNTHASE.
DR SMART; SM00827; PKS_AT; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 1766..2214
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 2300 AA; 244224 MW; 8D3499D14A83F3F6 CRC64;
MDEAWFPVLV REYPKPMPFV PVIDNDLLRW WGQDQLWQSE DSRYSADSVR IIPGPISVAG
ITTVDEPVAD ILGRFEEAMV KRVSAESPSA DKTAFAQLGA ASSAEEFIRK SPNISWVGHL
MANPAYGTSN GDANYEIRKI SSEGSIEKYD LDIHLDTYWD NDPDGGASKH AVRDIVIPLN
VDGNESGLFP VVDRDRLPEH VYRMLADTAG IGNTAITGDK LTAMPVIEQV ADKAAHPFGQ
AHTSYTLSAN LGFDHEAATG GALPSNLVPS RIAPDALVGP AWPAIYAALG SVYVNGFPVI
EGLLNAVHLD HLIELEVSED ELLKHTGEQI ALTSWAENYF ESASGRVVTI HVTHSAQDGT
VLANETERFA IRGRAYSDAL PPEAPDYGGI EAEIESTPRR LLRRVKVTAP HEMTAFARTS
GDFNPIHTSH RGAAVSGLAA PLVHGMWLSA TAQYAVQALD GKGAHYEIAG WTYNMYGMVQ
LDDEVEISVE RVGRVAHSGM VLEVTSRIDG NIVSRGTAIV RAPKSAFVYP GQGIQQQGMV
LDERAKSPAA RDVWERADKV TCEKLGFSIL AVVRDNPKEL TANGVTYRHP EGLLNLTQFT
QVALATVAFA QTARLREAGA DIWPAYFAGH SLGEYNALSS FAGVIPLETV IELVFHRGST
MHHLIPRDAK GRSNYRMGAL RPNQFGVGDD GVREYVESVS KASGEFLQIV NYNLAGQQYA
VAGTIAGLKA LKADSARRVA EYGGKPAFML VPGIDVPFHS TLLRKGVPEF RDKLDALLPQ
TIDYRGRLVG RYIPNLVAAP FEMTKEFAAK ILEVVPSERI QAALDDPQIW DSYAADDQKL
GRLLLTELLS WQFASPVRWI ETQALLFGSA EQGGLGVEEY VEVGLGNAPT LANLGAKTLR
LPQFAGRDVT VYNVGRDEGR VYMTDSDSLV PEEDADDSAV AAAASSAAAA PAVASAPAAA
PAAVAEVPVA AASAGAPSGA AVADIPFKAS DAIATLLAYS AKVRPDQIGE SDTTDTLTNG
VSSRRNQLLM DISSELGVAS VDGAAEATVK ALSALVNKVA PNYKAFGPVL SDIVRDRVRG
MFGAAGVKLG QITKRVTDTW QLGEGWTSHV VAALVLETRE GASSRGGDLA SLSTDAASNA
AAANALIDAA VQKVAADKGI AVAMPSAGGA AGGAVVDSAA LDAFAAKVTG ADGVLASTAK
FVLNQLGVAA PVAEETADEN AAVVAAVEAE LGADWPKQVE PRFDERKAIL FDDRWASARE
DLARAYYNND ESALNGSFIG LGKTIADEAA WYAGKSDNAD LKAAFNRVAA EAGENASESA
ETSRFAGDIA VVTGVAPNSI AAQVVNGLLA GGATVVATSH SFKPSVKAWA KQTYREHAAG
DAKLWLVPAN LSSYRDVDAL VTWVGNVQKK TSGATTTILK PAYEPSLFFP FAAPPVHGSL
ADSGELFESQ ARLMLWGVER AIAGLAKIGA DTDVQHKLHV VLPGSPNRGI FGGDGAYGEV
KSAFDAIVNR ARAEKVWSSR VTFAHPKIGW VRGTGLMGGN DPLVEVVERH GLKTYSTAEI
AVELLNLSTR ESRIEAAKAP LDVDLTGGLG NEPIDIKALR AEAMEDAAQA EAANAKNAIA
GNESDTAAKT LIKALPSPRA PRQAKVDLAD WQNVSARPED EIVIVSVGEL GPWGSGRTRF
EAELGIHSDG QVDLSAGAVL ELAWNMGLLT WNDSPKPGWY DVDGNLVPEE DIAERYHDEV
VARSGVRPFD EGMGNDYKDG TDEEEAEVFL DHDVTFSVPT REIAEEYVKL DEAHTSFAAD
AESGEWNVTR HAGSMIRVPR RAAMTRTVGG QFPKGFDPVK WGIPASMVGD VDKIALWNIV
TTVDAYLSAG FTPTEILEAV HPSMVASTQG TGFGGMASMR KLYLDRFLNH EIPTDILQEA
LPNVVAAHVM QSYIGGYGNM VQPVSACATA AVSLEEGADK IALGKADFVV TGAIDDIGVE
SVIGFGNMNA TANSEEMYAK GIDARFFSRA NDRRRGGFVE SQGGGTILLT RGDIALKLGL
PVAGVIGFVH SYADGAHTSI PAPGLGALAA GMGGKDSKLV RDLARLGVTP DDIAVVSKHD
TSTNANDPNE SELHNTLAHA IGRADGNPLF VISQKTLTGH AKGGACIFQV NGLTQLFKSG
VIPANAALDC VDPKLMRDDH MVWLREPLKV GSVKAGLATS LGFGHVSGFA AIVNPGAFEA
AVANTAGVEA LNAWRDRANE RLAAGQRRLE EGMMGRAALY EPIDNRRFHE DGRGYNAHEV
EKAMLLDPNA RLGASGYFEA
//
