ID R6PKT8_9CLOT Unreviewed; 756 AA.
AC R6PKT8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Acyl-coenzyme A synthetases/AMP-(Fatty) acid ligases {ECO:0000313|EMBL:CDC10392.1};
GN ORFNames=BN649_01718 {ECO:0000313|EMBL:CDC10392.1};
OS Clostridium sp. CAG:413.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262803 {ECO:0000313|EMBL:CDC10392.1, ECO:0000313|Proteomes:UP000018076};
RN [1] {ECO:0000313|EMBL:CDC10392.1, ECO:0000313|Proteomes:UP000018076}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:413 {ECO:0000313|Proteomes:UP000018076};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC10392.1}.
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DR EMBL; CBES010000060; CDC10392.1; -; Genomic_DNA.
DR AlphaFoldDB; R6PKT8; -.
DR STRING; 1262803.BN649_01718; -.
DR Proteomes; UP000018076; Unassembled WGS sequence.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd02209; cupin_XRE_C; 1.
DR CDD; cd00093; HTH_XRE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR001387; Cro/C1-type_HTH.
DR InterPro; IPR013096; Cupin_2.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF07883; Cupin_2; 1.
DR Pfam; PF01381; HTH_3; 1.
DR SMART; SM00530; HTH_XRE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50943; HTH_CROC1; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CDC10392.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018076}.
FT DOMAIN 18..72
FT /note="HTH cro/C1-type"
FT /evidence="ECO:0000259|PROSITE:PS50943"
SQ SEQUENCE 756 AA; 85220 MW; A6A44961BA6B98BB CRC64;
MMNTTNTMMQ LSEIAERIRE LREIMGWSAA EMADKTEVTP EAYALYESGS ADIPFTFIHK
CALAFNVELT ELLEGRSAHL SSYTVTRKGK GQETAKEDGI EIMNLAPKFR DKIAQPYWVH
YEYSPEQQNA PIHLTKHSGQ EFDLILKGKL KVQVGEHTEI LGEGDSIYYN SSTPHGMIAV
DGEDCYFCAV VLPGDDVKEE TVRSTIVSAQ SSEKLLCEKF VKTHEDEHGR LKSIEFKNTD
TFNFGFDIVD EIANKYPDKL AMLHLDSERN ERRFTFKDIK KASNQCANYF TSLGVKKGDR
VMLVLKRHYQ FWFAIVALHK IGAIAIPATN QLKEHDFEYR FNAAGVSTIV CTGDGDTADI
AERAAQKCPT VKNKLIVGRQ KEGWHDFNAE YKLFSSKYER TPDTSCGDDT AIMFFTSGTT
GNPKMAAHKH TYALGHFVTA KYWHCCERDG LHLTISDTGW GKSLWGKLYG QWLCEGAVFV
YDFDRFDASD ILPMFAKYNI TTFCAPPTML RMLIKEDLSK YDLSSIHHMT TAGEALNPEV
FRQFKAATGL EISEGFGQTE TTLTIANLRG TPLKLGSMGK ASPQYDVDLV DQDGNTVAPG
ETGEIVIRTS RAVPCGLYKE YYLDSEKTEE AWHDGLYHTG DTAWRDEDGY FWYVGRKDDV
IKSSGYRIGP FEIESVIMEL PYVVECGVSA APDEVRGQVV KASIVLTKGT EPTEELKKEI
QNYVKSHTAP YKYPRVVVFK DELPKTTSGK IQRYKL
//
