ID   R6RF38_9FIRM            Unreviewed;       701 AA.
AC   R6RF38;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=Penicillin-binding transpeptidase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BN652_00578 {ECO:0000313|EMBL:CDC43944.1};
OS   Firmicutes bacterium CAG:424.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263022 {ECO:0000313|EMBL:CDC43944.1, ECO:0000313|Proteomes:UP000018167};
RN   [1] {ECO:0000313|EMBL:CDC43944.1, ECO:0000313|Proteomes:UP000018167}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:424 {ECO:0000313|Proteomes:UP000018167};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC43944.1}.
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DR   EMBL; CBFI010000033; CDC43944.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6RF38; -.
DR   Proteomes; UP000018167; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR007887; MecA_N.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627:SF25; PENICILLIN-BINDING PROTEIN 3; 1.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   Pfam; PF05223; MecA_N; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF54427; NTF2-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018167}.
FT   DOMAIN          47..155
FT                   /note="NTF2-like N-terminal transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF05223"
FT   DOMAIN          163..343
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          380..686
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   701 AA;  78123 MW;  0E523106A76BF46B CRC64;
     MAKKKSKKKR KQQKKRVLCL VSVVLVAVVG AGGVLLYKKM TEKTREDIIK EYMGYIEKKE
     YEKMYALLDE VSKDKVKQED FITRNQNIYE GIEAEKIQLD IPEEQDKDQP LSYRVTMDTL
     AGEITYDADT FFEKEKGQWH LVWDDSVIFP GLESKDKVSV SSVEAKRGSI YDRNDVLLAG
     QGEVESVGLV PGKMNIQAEE DIEDLAEILG TTAEFIEKQL DASWVQQDSF VPLKKMTQEQ
     LDEAYVPKEG AESAGGSIQD KLLEYPGVLI SKVESRVYPY GECTAHLLGY VQQINAEELE
     EMKGKGYNEQ SVIGKSGLEK LYEDRLREKK GYRISILDEQ GEEKQALAVK PAEDGENIKL
     NIDIRWQQKL YEAYQEDKSC SVVMNPKSGE VLALVSTPSY NSMDFVLGMS QETWDALNND
     PNKPMYNRVR ETWAPGSSFK PIVGAMGLTT GAFTEEEDLG ASGLAWQKDE SWGNYKVTTL
     HEYSGGAVLK NALIYSDNIY FAKAALKIGA ETFTGELDKM GFNQEIPFDI GMTSSQYSNS
     EAIDSEVQLA DSGYGQGQML VNPLHLACMY SAFFNEGNMI TPYLEYEEGK TASYWAEGVF
     TPEAANIIYE DLKEVVSNPN GTGYGASKAV GVTLAGKTGT AEIKATQEDE NGTELGWFAV
     YNTGVADSDT ILMLNMVEDV KGRGGSGYVV NKDVEIWNQM Q
//