ID R6UAB8_9CLOT Unreviewed; 797 AA.
AC R6UAB8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN818_01738 {ECO:0000313|EMBL:CDC82668.1};
OS Clostridium sp. CAG:964.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262848 {ECO:0000313|EMBL:CDC82668.1, ECO:0000313|Proteomes:UP000018136};
RN [1] {ECO:0000313|EMBL:CDC82668.1, ECO:0000313|Proteomes:UP000018136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:964 {ECO:0000313|Proteomes:UP000018136};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDC82668.1}.
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DR EMBL; CBFZ010000093; CDC82668.1; -; Genomic_DNA.
DR AlphaFoldDB; R6UAB8; -.
DR STRING; 1262848.BN818_01738; -.
DR Proteomes; UP000018136; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 2.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000018136}.
FT DOMAIN 19..339
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 340..615
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 40..47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 797 AA; 90605 MW; 0C762B8B84740C44 CRC64;
MDYTKLTKLR NRLMENEFSR MNNMQQEAVF TTKGPVLILA GAGSGKTTVL VNRIANLVSW
GSAYNSGYFK EELSEDEIAL IEDAAYNKTE VPLEIKKKLF VNPAKPWQIL AITFTNKAAG
ELKERIIARV PEATDIWAST FHSSCARILR RYGDRLGYTN NFTVYDTDDQ RRQMKEILKS
MNVDEKILPH RSVLTEISRA KDKLQSPEDF AKETFNDSRR ITIAKAYAVY AERLKSSDAM
DFDDLIYNTV RLFQENNDVL EYYQNLFKYI MVDEYQDTNM AQYRLISMLA EKNRNICVVG
DDDQSIYKFR GATIENILSF EENYPDGKVI RLEQNYRSTQ TILDAANGVI AHNEERKGKT
LWTDNPKGDK IVVHTASSER DEAKYITDII LDEVEKGRKF SDFAVLYRTN AQSNIIEQNM
ARSGIPHRLI GGHRFYDREE IKDMTSYLQV VSNPSDNIRL RRIINKPKRA IGPATVDKAS
EIAAVTGESL YYVISHADQY EPLKRAVPKL QKFTKLIEDL IEYAEDEDTT ICQLYNEILE
RTDYIECLKK EKEDSESRIE NINELMTNIK NYEDDNPEDA TLSGFLEDIA LLSDIDNYDA
DADSVVLMTL HSAKGLEFPV VFIPGAEEGI FPGMQSITNP NELQEERRLA YVGITRAKEK
LYIIHAQERM LYGSTSRNML SRFVNEIPKE LAEVTSSVVK TSFTSPTSYS SKSSANSGFL
NSTFAKANSF ANKTYQSPAA PKKSASYKAG DQVMHKAFGK GMVVSATPMA NDTMLEIAFD
KVGTKKLMAN FAKLEKI
//
