ID R6W204_9BACT Unreviewed; 1265 AA.
AC R6W204;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=alpha-L-rhamnosidase {ECO:0000256|ARBA:ARBA00012652};
DE EC=3.2.1.40 {ECO:0000256|ARBA:ARBA00012652};
GN ORFNames=BN725_01485 {ECO:0000313|EMBL:CDD05043.1};
OS Prevotella sp. CAG:592.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Prevotellaceae;
OC Prevotella.
OX NCBI_TaxID=1262931 {ECO:0000313|EMBL:CDD05043.1, ECO:0000313|Proteomes:UP000018343};
RN [1] {ECO:0000313|EMBL:CDD05043.1, ECO:0000313|Proteomes:UP000018343}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:592 {ECO:0000313|Proteomes:UP000018343};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing alpha-L-rhamnose residues
CC in alpha-L-rhamnosides.; EC=3.2.1.40;
CC Evidence={ECO:0000256|ARBA:ARBA00001445};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD05043.1}.
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DR EMBL; CBGI010000094; CDD05043.1; -; Genomic_DNA.
DR AlphaFoldDB; R6W204; -.
DR Proteomes; UP000018343; Unassembled WGS sequence.
DR GO; GO:0030596; F:alpha-L-rhamnosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR035396; Bac_rhamnosid6H.
DR InterPro; IPR035398; Bac_rhamnosid_C.
DR InterPro; IPR013737; Bac_rhamnosid_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008902; Rhamnosid_concanavalin.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR036278; Sialidase_sf.
DR PANTHER; PTHR33307:SF10; ALPHA-L-RHAMNOSIDASE; 1.
DR PANTHER; PTHR33307; ALPHA-RHAMNOSIDASE (EUROFUNG); 1.
DR Pfam; PF05592; Bac_rhamnosid; 1.
DR Pfam; PF17389; Bac_rhamnosid6H; 1.
DR Pfam; PF17390; Bac_rhamnosid_C; 1.
DR Pfam; PF08531; Bac_rhamnosid_N; 1.
DR Pfam; PF13088; BNR_2; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000018343}.
FT DOMAIN 196..366
FT /note="Bacterial alpha-L-rhamnosidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08531"
FT DOMAIN 376..475
FT /note="Alpha-L-rhamnosidase concanavalin-like"
FT /evidence="ECO:0000259|Pfam:PF05592"
FT DOMAIN 480..840
FT /note="Alpha-L-rhamnosidase six-hairpin glycosidase"
FT /evidence="ECO:0000259|Pfam:PF17389"
FT DOMAIN 843..920
FT /note="Alpha-L-rhamnosidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17390"
FT DOMAIN 960..1247
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13088"
SQ SEQUENCE 1265 AA; 143066 MW; 6E185B8A079CBA45 CRC64;
MTAALALFVI GSEATAREMA SASKMMSASQ KTTTRKKTTA RKKATGIKVV DLRTERMVSP
MSIGTTTPRL GWRITADKND VRQRRYHIIV ASSKDNAMQG IGDLWDTTAD SDQSQWVEYA
GKPVRSNTTC YWRVKVETTQ GDSEWSDVAM WNVGLISESD WSGQWIGFDA AKPWDKEELH
SKLSSRYLRR EFSLDKAVRK ATLYISGLGM YEAFINGKKV GEQVLAPAPT DYRKTVVYNA
FDVTDMMQSE NAIAVALGNG RYYTMQQKKK PYKITNFGYP KLRANIIIEF ADGTKKTIST
DTKWKLNADG AIRSNNEYDG EIYDARKEFK GWTTAGYDDS KWENAERTAI PTGTLRGAMS
PNMKVMKQMP AQTITMHGDT AIIDLGQNIA GWLKMRVENT ASGDSIKIRF AETLTPDGRL
YRENLRHALT TDCYVADGTE KGKWWNPTFV YHGFRYAEIT GLRSPKKEDF IGEVVSDEME
KTGTFTCSDT ILNKVYHNAE WGILANYKGM PVDCPQRDER QPWLGDRTRG CLGESFIFDN
NLLYNKWDRD ITEAQREDGC IPDVAPAYWN YYSDNITWPA ALPFSMEMQY DQFGDLSAIS
RYYPAAKKWI THMGYQYEKD GLMPRDKYGD WCVPPEDIKM IHSKDPNRTT DGTLIATAYY
YRLNKMMERF AGILGKSDDA QTFAKKAEEV KTAFNSKFLT IKKDTHEAYG GLLYPDSTFY
GNNTCTANLL PLAFGMTDDP YVKTEVEKNI LKNIITLNKG RIPCGVIGVQ WIMHTLSDMG
RTDVAWLLAT NKAYPSWGYM AENGATTTWE LWNGNTASPK MNSGNHVMLL GDLVSWIYQD
LGGINSDPDN PGYKHIILKP DFSVDEIDDI STSYKSIYGN IQSKWKKQNG MLHWQVEIPA
NTTATLHMPD GTTRETGSGK YSFTEKLPMR DSSIVTDEFL YTKATFPECH SATIAETTKG
DLVATYFGGT KERNPDVCIW VSRKVKGSKE WTKPQMVADG IINDTLRKAC WNPVVYQIPQ
GDLVIYFKIG SKVSDWSGWM VRSKDGGKTW SKREPLQKDF LGPVKNKPVM SRGRLIAPSS
IESNGWRLYF EYSDDMGKTW QRTDYVEADS ITIEGKKKLK DLAIQPSIIS LKDGRLAALA
RTRSEHIGIT YSEDNGKTWS KLKLIDTPNN NSGLDAVTLS DGNHVLICND KPIPNGIKNG
KGLRTPLSLM TSSDGESWQH WMTLEDSPIS QYSYPSIIQT SDGHIHCIYT WRRQRIKHVE
VRTDK
//
