ID   R6WKC7_9FIRM            Unreviewed;       437 AA.
AC   R6WKC7;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase {ECO:0000313|EMBL:CDC94602.1};
GN   ORFNames=BN546_00736 {ECO:0000313|EMBL:CDC94602.1};
OS   Firmicutes bacterium CAG:227.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263010 {ECO:0000313|EMBL:CDC94602.1, ECO:0000313|Proteomes:UP000018294};
RN   [1] {ECO:0000313|EMBL:CDC94602.1, ECO:0000313|Proteomes:UP000018294}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:227 {ECO:0000313|Proteomes:UP000018294};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDC94602.1}.
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DR   EMBL; CBGC010000256; CDC94602.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6WKC7; -.
DR   STRING; 1263010.BN546_00736; -.
DR   Proteomes; UP000018294; Unassembled WGS sequence.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR   PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR   PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018294};
KW   Transferase {ECO:0000313|EMBL:CDC94602.1}.
FT   MOD_RES         216
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   437 AA;  47818 MW;  19D06093BB9D6B09 CRC64;
     MSEKITRENR KFKFETLQLH VGQEKPDPVT DARAVPIYQT SSYVFRNCDH AAARFGLADA
     GNIYGRLTNP TEDVFEQRMA ALEGGVAALA VASGAAAITY TIENLAQNGD HIVSAKNIYG
     GSFNLLLHTL PQYGVTTTFV DIFNYDEVEA AIQENTKAIY IETLGNPNSD VVDIEALANI
     AHKHKIPLVV DNTFATPYLV RPIEYGADIV VHSATKFIGG HGTTIGGVIV DSGKFDWEGS
     GKFPSLTEPN PSYHGISFTK AVGPAAFVTK IRAILLRDTG ATISPFHSFI FLQGLETLSL
     RVERHVENAL KVVEYLNNHP QVEKVHHPSV SDDATQKELY AKYFPNGGGS IFTFEIKGDA
     QKAKDFIDNL ELFSLLANVA DVKSLVIHPA TTTHSQCTEE ELLDQGIKPN TIRLSIGTEN
     IDDIIQDLDE AFKAVQD
//