ID   R6XJC3_9FIRM            Unreviewed;       417 AA.
AC   R6XJC3;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=FAD-dependent pyridine nucleotide-disulphide oxidoreductase {ECO:0000313|EMBL:CDD21660.1};
GN   ORFNames=BN602_00665 {ECO:0000313|EMBL:CDD21660.1};
OS   Firmicutes bacterium CAG:313.
OC   Bacteria; Bacillota.
OX   NCBI_TaxID=1263017 {ECO:0000313|EMBL:CDD21660.1, ECO:0000313|Proteomes:UP000018373};
RN   [1] {ECO:0000313|EMBL:CDD21660.1, ECO:0000313|Proteomes:UP000018373}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:313 {ECO:0000313|Proteomes:UP000018373};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDD21660.1}.
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DR   EMBL; CBGQ010000021; CDD21660.1; -; Genomic_DNA.
DR   AlphaFoldDB; R6XJC3; -.
DR   STRING; 1263017.BN602_00665; -.
DR   Proteomes; UP000018373; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR023753; FAD/NAD-binding_dom.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   PANTHER; PTHR43073; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR   PANTHER; PTHR43073:SF2; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF07992; Pyr_redox_2; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   SUPFAM; SSF51971; Nucleotide-binding domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018373}.
FT   DOMAIN          8..99
FT                   /note="Dihydroprymidine dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF14691"
FT   DOMAIN          116..357
FT                   /note="FAD/NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF07992"
SQ   SEQUENCE   417 AA;  46559 MW;  A6CC941FC8E7F859 CRC64;
     MREKLDNIKN IAQRCLKCKK PLCKEYCPLH NNIPVILNYI NNDQIVEAKK ELLKTTNMSF
     ICSKLCDHEK SCYGHCALRN TSDGSIAFYE VENYLSTLIS ESDYEKISKN KIKSKIAVIG
     AGVSGMNVAI ELAKLGLDVT LFDKNNQIGG VITDSLPNFR FNDNVVNTLV AILNKLNVEM
     VFNKEFGNNL NFDDLNNFDY IVFATGTMLS KKIFGDNASV YDGIKLLEDG KNNIQEINNA
     NSLVIGAGNV AMDVSRLLVR SDNKVNIVYR RNIANSPASK KEIEMAINDG VNFIELRSPK
     QLVFDKANKL IGLEVEITEL IKDDNSTRLS FKGTGECETI PCDIVVEALG TNANYDYLKS
     FIPDLFDEKG WPNSKIYKYK NQKVLLTGDY LTGASSFAGA VATSNKTIEL IKEDIWK
//