ID R7BVK5_9BURK Unreviewed; 1630 AA.
AC R7BVK5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BN641_00848 {ECO:0000313|EMBL:CDD69527.1};
OS Sutterella sp. CAG:397.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sutterellaceae; Sutterella.
OX NCBI_TaxID=1262976 {ECO:0000313|EMBL:CDD69527.1, ECO:0000313|Proteomes:UP000018105};
RN [1] {ECO:0000313|EMBL:CDD69527.1, ECO:0000313|Proteomes:UP000018105}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:397 {ECO:0000313|Proteomes:UP000018105};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD69527.1}.
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DR EMBL; CBHO010000012; CDD69527.1; -; Genomic_DNA.
DR Proteomes; UP000018105; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF150; ATP-DEPENDENT DNA HELICASE RECQ; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00580; UvrD-helicase; 2.
DR Pfam; PF13361; UvrD_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000018105}.
FT DOMAIN 289..469
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 499..646
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1061..1478
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 1082..1089
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1630 AA; 180419 MW; 90051245AEE99F81 CRC64;
MTTTAKDPMA AVPSQAFARV VFVDCETNGT GTELLDFGAA DTAGEVLHST TPEAVRSFIG
NARFLCGHNV FALDKRFTTA LTGLVPGGHA WIDTLALSVL LFPQKRFHAL LKDEKLLTGE
MNNPATDALK ARDLFFEELT AWQKLAPAVR TILAALLSRD IRYRGFFAYA GETPAEDSAE
NLARTIREAF PDAFCANANL PLLIKTKPAD LGLVLAFLAA GDSAELLPLW TVKTFPAAED
VLTALCGTPC RAGCPWCSRT FNARHGLKTI FGFEAFRTYG GEPLQERAAQ AALEGDSLLA
VFPTGGGKSI TFQIPALMQA KATRSLTVVI SPLQSLMKDQ VDNLTAKGIG GAYTVNGLLS
PVERARAFDA VVTGEASLLY ISPEQLRSVS IERVLSTRRI ARFVIDEAHC FSAWGHDFRT
DYLYIGDFIA RLEKLQGARH RIAVSCFTAT AKQKVIQDIC EYFREKLGLE LKLFTTEEAR
KNLRYKVLHA ENDAEKMTLV RELLSRHPCP TIIYMSSTKG TEKLVEKLTA EGFKALPYHG
QMDAALKIEH QEAFLSGAAQ VITATNAFGM GVDKKDVGLV IHYDISASLE NYVQEAGRAG
RDPNLEADCY VLFNEDDLDR HFAMLTQSKL SQADIQLVWR AIKQMTRTQE SVPVSALELA
RTAGWDTETI PDLETRIKTA LSALETAGYI RRGRNVSRVY ATSIAAKSFE EARQRMEVSP
YFQDDESRVR AGRILQALIS KRSRSKADAG ESRTDYLSDR LGIPVDKVVE SVNALKLAGI
LRNENDMAGV LMKNARTKTA DAVRLEQFLF TELSKAEHVT EVNLKALNAA AGAAGLTRIT
PRLIGTLLRH MKRTGVLSNL HTIPATSVVR IKKAETFADA LESLPVKAAL SEFILTTFEK
AARAEPPEGA ARETAFSTTG LLTAWEEDAF RQQAYSQKVT VRDIENTLLF MADAGALRLQ
GGFMVLYQGM LITRLVTDPK RRYRAEDYKL LDGYYRQKLQ QIHIVGEYAN LMMRDYEAAL
TYVHDYFALD YNVFLRKYFA ADRREEMRRG MTAARFKKLF ADLTETQFSI IDEKAQFVVV
AAGPGSGKTR VLVHKLAALL LLEDVRPEQL LMLTFSRAAA GEFKKRLIEL IGKKAAYVDI
KTFHSYAFDL LGRPGTLEET RDVVSRAAAL VKAGGADPAR TAKTTLVIDE AQDMSREDFE
LVMSLIDSNN ALRVIAVGDD DQNIYAFRGS DSRYLKELLL DKDAARYEMT ENWRSTPAIV
TLADAFAGML HGRLKTTPNR AVKTENGIVR IVRHTRPGFE AAISEEIAAA LKAGTLKGST
ALLTITNEEA RLCAVLLADA GVRVRLIEGE KKLNFCDLLE TRTLLHFLKK RAGAGGLIEK
GVWNEARDFV KDRYQGSPWV ENVTTVMKAF EGLTPTEHLY LSDFADTVTE LKLEETYTAA
RGLVTVSTMH KAKGREFENV WLLASRTTYP DDEARRVLYV AMTRAKTNLF VHAASGVLSD
FTVEGVEHSI DTRTFPAPRE IAVALGHDDV FLDWFIARKQ RIFTMTAGML LTPAEHGLTI
AGPEGCDMIV RFSKSFEEKL AGLTAKGYRL TRAAIRAIVA WKKTEDETLY PVVLPELRLT
KATDNAVISP
//
