ID R7CSW9_9FIRM Unreviewed; 1178 AA.
AC R7CSW9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Chromosome partition protein Smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN Name=smc {ECO:0000256|HAMAP-Rule:MF_01894};
GN ORFNames=BN625_00050 {ECO:0000313|EMBL:CDD81095.1};
OS Dialister sp. CAG:357.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Dialister; environmental samples.
OX NCBI_TaxID=1262869 {ECO:0000313|EMBL:CDD81095.1, ECO:0000313|Proteomes:UP000018365};
RN [1] {ECO:0000313|EMBL:CDD81095.1, ECO:0000313|Proteomes:UP000018365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:357 {ECO:0000313|Proteomes:UP000018365};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for chromosome condensation and partitioning.
CC {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- DOMAIN: Contains large globular domains required for ATP hydrolysis at
CC each terminus and a third globular domain forming a flexible hinge near
CC the middle of the molecule. These domains are separated by coiled-coil
CC structures. {ECO:0000256|HAMAP-Rule:MF_01894}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC3 subfamily.
CC {ECO:0000256|ARBA:ARBA00005917}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDD81095.1}.
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DR EMBL; CBHT010000192; CDD81095.1; -; Genomic_DNA.
DR AlphaFoldDB; R7CSW9; -.
DR STRING; 1262869.BN625_00050; -.
DR Proteomes; UP000018365; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030261; P:chromosome condensation; IEA:InterPro.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01894; Smc_prok; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR InterPro; IPR011890; SMC_prok.
DR NCBIfam; TIGR02168; SMC_prok_B; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR PANTHER; PTHR43977:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_01894};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01894};
KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01894};
KW Reference proteome {ECO:0000313|Proteomes:UP000018365}.
FT DOMAIN 522..640
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT REGION 313..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 699..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 234..275
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COILED 989..1019
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
FT COMPBIAS 825..856
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01894"
SQ SEQUENCE 1178 AA; 133488 MW; A80022CEFED0BADB CRC64;
MKLLRLILQG FKSFADKTTI EFADGMTVIV GPNGCGKSNI SDAVRWVLGE QNVRNLRGQK
SEDIIFAGSE SRTRKNGAEV TLVLDNSNRE LPLDTAEVSI TRRILRNGDS DFQINKRNCR
LKDIHELLAN TGLGKGSLAI IGQNRVDEVL TAKPEERRAI FEDVAGISLY RMRKNEGLQK
LVKTAENMDR VKDMMAMLDE QTGPMKEKAE KAKAYKALAA EKRAVQATMS ALKLDSIKES
LEKHKAETET LEQDSVKWKA ELTKAAAALA KLEQETLLHQ EKVKKAGTDF AEAKEKLDGI
RVDYKIKEEA LEQEKKRTEE LKEDEEDQKE AEEELIEEIQ NDEEEMKAAE AEKADWLAKQ
NQAEAEKEKL AGELEASEKA YSEILNFSRQ KMAEKQKLEQ GLAYLDNEVR RLKGESSRRE
EAAKSIEGEL QKTNEALASL LAEEKEAMAR QEQLKEEGIR DRKALDEARN ECFSIGNELN
EAESSFRTIH SRREYLEKAD KEYASFSRTT KTVMENRAIF GDAVHGALGE LIHVPSEYTA
AAEVALGSQI SNIVTDTTKS AGDIIRWLKE KNLGRATFYP LESMKPSSYS GREQEASREE
GILGIAADLF ETDSLYQDLL HSLLGRTLIA KDLDAARRVS KKYGYRLRIV TLDGQIVNAG
GSMTGGSMKK KENTYFGRKE EIKELYAEEK KREKDLADLR KRKQEKETAR DSLSEKVAGE
RESWHQMDLA LASFKGQKDG LEKTKTDQET RLKEGKDALA SISESLEKSV QQMTEGWELL
KTYEDIPEPG KDEKSLAIRK QIDDKAGELI AIREGLTKAE SRASFAKRMM NDAKKAQEDQ
KKDREDLENK KKANEEAKKN LAETLEKLNQ DFEEANGKWE SIRTKQESLQ GETDRYAALE
RDSQAAWRKA QEKSSSVEKD LADKKARLER FKEEEAEELQ KISEEGMTRE EVETLKLPGT
LNEMKNRDKV LAGKIADLGT VNPAGEEEYE EHLKKRNFYE EQINDMRGAE EELRTVIKDI
DEKMASQFDE AFTKVNQEFG RIMQIMFQGG SAKLELTDPE HPLECGVEMY LQLPGKKRQP
LTLMSGGERA LTVIALLISF MAYRPAPFCF VDEIDAALDD SNVDRYSRMI AEYKKKTQFI
VISHRKRTME FADTLQGVTM GEKGVSSLVT VKMKDYVE
//
