ID R7ETM7_9FIRM Unreviewed; 1026 AA.
AC R7ETM7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Beta-galactosidase {ECO:0000256|ARBA:ARBA00013303};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=BN640_01720 {ECO:0000313|EMBL:CDE05613.1};
OS Anaerotruncus sp. CAG:390.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Anaerotruncus.
OX NCBI_TaxID=1262703 {ECO:0000313|EMBL:CDE05613.1, ECO:0000313|Proteomes:UP000018385};
RN [1] {ECO:0000313|EMBL:CDE05613.1, ECO:0000313|Proteomes:UP000018385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:390 {ECO:0000313|Proteomes:UP000018385};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE05613.1}.
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DR EMBL; CBID010000282; CDE05613.1; -; Genomic_DNA.
DR AlphaFoldDB; R7ETM7; -.
DR STRING; 1262703.BN640_01720; -.
DR Proteomes; UP000018385; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023001};
KW Cellulose degradation {ECO:0000256|ARBA:ARBA00023001};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023001};
KW Reference proteome {ECO:0000313|Proteomes:UP000018385}.
FT DOMAIN 744..1014
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
SQ SEQUENCE 1026 AA; 115645 MW; 0A2A62DB566F0CD8 CRC64;
MSFDYDFHKS QKILHVGCEK PRAYYIPFDS DAGAASAGDR RAESGRFLSL CGDWDFIYYP
TPAEIGDFTA EGFDASAEFE KMTVPASWQS FTDRGYDTPN YTNVNYPFPV DPPHVPDANP
SALYRREVYI SAEKLEGREV YLNFEGVDSC FYLWVNDSFV GYSQVSHMTS EFNVTDKLRA
GKNTVKVLVF KWCDGSYLED QDKFRFSGIF REVYLLFRDV RHIVDIYALP ELNASYSQGV
LGVDLTLAGG GESEIAYRLL SPDGKEESGG SIVLGDAGHF EMLVSKPALW SDETPALYTL
CISCGGEHIR IPVGFKDVRV KDKVIYINGK KVKAKGVNRH DSHPLLGSAT PYDHMLRDLY
ILKRHNVNMI RTSHYPNDPR FPGMCDRMGI YLCDETDFEA HGMSRVHDWD YFVREPEWTE
SLLDRVTRMF ERDKNHASVI MWSLGNESGM GDNQRVMADY LHCRMPGCLV HCEDVSRRLH
AWGAPDETKN TECPWVDVES RMYPSVEESR EYIDNKKYTK PFFLCEYSHA MGNGPGCLSQ
YWELIYSRDA FFGGCVWEFL DHSVAIGSDV YADPHYTYGG DFGDYPNDGN FCVDGLVYPD
RRPHTGMFEL KQAIKPFAVL DSDAAAGWVK IKNLRFFRTL EDLSLYWSIE SNGRVIADGS
VPALNIKPGT ARRINIASSG VKLCGECCLN ISVRQNRATE WAEAGYEVGF DQIMLESASE
VKTARALPAD AVVLDTSDEY FTVTAPAADT VYRVERANGL IISIVHAGKE LLTAPVKPTV
WRAPTDNDRV IKNEWFKAGY DRLSVKCYSC TAEASGKDVA VSAEISLGAP YRHPVLHASV
TYLFRTDGSV IPTLKAKVGD GLPMLPRFGL QLEMPYGMEY IRYFGRGECE SYIDKRLASK
LGVYSTTATE NFEHYVRPQE NSAHADTRWL TLATAAGHGI VVSMRKDPVS FNCCRFTPEQ
LAATRHDYEL KPLRGTVLNV DLRHTGIGSN SCGPQLAKQF RFEDKEFEFS FVLTPCFVNN
VDPFNM
//
