ID R7F3U9_9CLOT Unreviewed; 624 AA.
AC R7F3U9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=AMP-forming long-chain acyl-CoA synthetase {ECO:0000313|EMBL:CDE09954.1};
GN ORFNames=BN623_01315 {ECO:0000313|EMBL:CDE09954.1};
OS Clostridium sp. CAG:354.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262799 {ECO:0000313|EMBL:CDE09954.1, ECO:0000313|Proteomes:UP000018313};
RN [1] {ECO:0000313|EMBL:CDE09954.1, ECO:0000313|Proteomes:UP000018313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:354 {ECO:0000313|Proteomes:UP000018313};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE09954.1}.
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DR EMBL; CBIG010000005; CDE09954.1; -; Genomic_DNA.
DR AlphaFoldDB; R7F3U9; -.
DR STRING; 1262799.BN623_01315; -.
DR Proteomes; UP000018313; Unassembled WGS sequence.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43272:SF83; ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J; 1.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018313}.
FT DOMAIN 83..464
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 624 AA; 71308 MW; B28964E8BBC60C46 CRC64;
MRILRDFKLP DFKFPKMKME GMENIQEMQV NYDQIDQIKD KKLKNKYYEE THYKTVKEIF
KRSIEKYKNN IYILERPNHD HKAKFEEFTY ERFGNDAINL GTGLMKYLNL ANERIIIIGE
NTYYWYVSYF SILCGAGIAV PVDKELPNNE IENVIKRSHA AAVIYSKKKK DAIDKIKDNL
PMVKYFIEMN SDEPVQGRDV GIENVIAEGK KLTDAGNTEY MDVEIDPEEF KFLIFTSGTT
SQAKGVMLCH RNLAENVNAV SKYVKIYERD RFFSVLPLHH TYESSIGALL PFANGSSVAI
CGGLRYIVPD MQEAKPTAML AVPLLVESLY KKINQSIEKS GKAGLVNSML HLTNMLKSVG
IDIKRKVFKE IYDNLGGNMR IIVSAAAPID KKIGKWVQDI GIEFLQGYGL TETAPIAALT
PECDPRVGSV GLPVNCAQIK IHNPNENGEG EIWIKSQTLM LGYYEDEEAT KEVVHDGWFN
SGDIGYQDKD GYVYVTGRSK NVIVTQNGKN IYPEEIELLL SKIPEIQECM VYGKEVEGEK
ELIISVKVIP NMEEIENLHG KNLSEEEIHK IIWNKIKEVN KGLTSYKAIK NLEIKNDEFA
KTTTMKIKRY VELQKDKEKN ETKE
//
