ID R7I7U9_9CLOT Unreviewed; 562 AA.
AC R7I7U9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Regulatory protein MsrR {ECO:0000256|ARBA:ARBA00040752};
GN ORFNames=BN648_00528 {ECO:0000313|EMBL:CDE46592.1};
OS Clostridium sp. CAG:411.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1262802 {ECO:0000313|EMBL:CDE46592.1, ECO:0000313|Proteomes:UP000018022};
RN [1] {ECO:0000313|EMBL:CDE46592.1, ECO:0000313|Proteomes:UP000018022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:411 {ECO:0000313|Proteomes:UP000018022};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC and teicoplanin, as well as the synthesis of virulence factors.
CC {ECO:0000256|ARBA:ARBA00037178}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family.
CC {ECO:0000256|ARBA:ARBA00006068}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDE46592.1}.
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DR EMBL; CBIY010000176; CDE46592.1; -; Genomic_DNA.
DR AlphaFoldDB; R7I7U9; -.
DR STRING; 1262802.BN648_00528; -.
DR Proteomes; UP000018022; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.630.190; LCP protein; 1.
DR InterPro; IPR004474; LytR_CpsA_psr.
DR NCBIfam; TIGR00350; lytR_cpsA_psr; 1.
DR PANTHER; PTHR33392; POLYISOPRENYL-TEICHOIC ACID--PEPTIDOGLYCAN TEICHOIC ACID TRANSFERASE TAGU; 1.
DR PANTHER; PTHR33392:SF8; REGULATORY PROTEIN MSRR; 1.
DR Pfam; PF03816; LytR_cpsA_psr; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018022};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 114..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 198..355
FT /note="Cell envelope-related transcriptional attenuator"
FT /evidence="ECO:0000259|Pfam:PF03816"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..533
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 61926 MW; AE32096DC7BD542C CRC64;
MSKEQEDNRR VFHNRGTNEQ REQQRAGFSE NISNQIDDYD DFEFEDTDGL EAYLSDSVAQ
VSEDADMDQK QREVVGDLDL EPYDSVSSLG EDTDFEMDVQ EEPRSNKWSK KKKAFVGIGT
TLACLVVAVT LVVGWFMFRI NYENGGNYAQ TDMTPEELAA QATLPPRDEN QVLLDEKIVN
ILCIGQESIL DGDGANGRSD SMIIASMNTE DKTLKLVSLM RDSYVSIPGY RDNKLNAAFS
FGGGQLLCET ITRNFGIELD GYVIVDFKGF KKMIDKIGGV EIELTEAEAQ YLNTTNYISD
KKQRNVVPGK QTVTGTQALG YCRVRKRAAI NGENNDHGRT YRQRAVLSQA YAKVKDLSIT
EMVSLVNDLL PYVTTNIKAS DILNYAKVML QMGVPELQQL RIPIDGAYSG QNLYCGSSLV
LDFSKNNAAL WEFIYGDGHG DITTLNPGSD TSYNTNSDTN SSQSVPTYVP ATRVTRAPST
QVTKAPVTQT TKAPTVTAAP TVKATKEPTV TTEEPKPRET TPPRPRVTKA PVKTKEPVVK
TAAPTKAPVQ EPDEPSDDGS VG
//
