ID   R7L8Y0_9BACT            Unreviewed;       936 AA.
AC   R7L8Y0;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Putative Zn-dependent peptidase {ECO:0000313|EMBL:CDE85164.1};
GN   ORFNames=BN601_01835 {ECO:0000313|EMBL:CDE85164.1};
OS   Coraliomargarita sp. CAG:312.
OC   Bacteria; Verrucomicrobiota; Opitutae; Puniceicoccales;
OC   Coraliomargaritaceae; Coraliomargarita.
OX   NCBI_TaxID=1262865 {ECO:0000313|EMBL:CDE85164.1, ECO:0000313|Proteomes:UP000017918};
RN   [1] {ECO:0000313|EMBL:CDE85164.1, ECO:0000313|Proteomes:UP000017918}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:312 {ECO:0000313|Proteomes:UP000017918};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDE85164.1}.
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DR   EMBL; CBJS010000221; CDE85164.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7L8Y0; -.
DR   STRING; 1262865.BN601_01835; -.
DR   Proteomes; UP000017918; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 3.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 3.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017918};
KW   Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..936
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004450974"
FT   DOMAIN          42..172
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          200..253
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          687..864
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   936 AA;  104483 MW;  7D7CCB7493CCBA19 CRC64;
     MMKKLTFLIM ALVANTLIGA PMLAPDPNLL VEKLDNGLTI AVYRNAEPPK RVSMRLLVTR
     GSAFETERER GIAHFIEHMA FNGTKHFPAG EMVEYFQRLG MAFGADTNAH TGFRETVYKL
     DMPEVSQKLV DDGLMLLRDY ADSILFEQSA IDRERGVILA EKDSRDNQDY RKAVKEIGHY
     FKGSIYPDRM PIGEKDVIKN VNKADFQKFY RATYRPENIV LVIVGDVDAK EIASTAKKYF
     GDMKPSPEEP PREANMGNLE TSDFEFDFGA DSMPVDAVYD STSNTPKSYA SLSVAKELKN
     MPDSLEKRVE DYRIRALSNA ISARYLRVAD KPASKISQGS AGSFEFDSFC RVFIFSSEAP
     VTKFADALEE NFRQLMSIHN ITNAEIENAK KKIFDSIESE IKAKQTRKNQ ALANEITSAF
     SESSVFTSPE TDLEIAKYAL KDFGAADAVK LLKSLFDGAK IKVFVSDTEA EMPAGELGKI
     AAAAFEKARK STYDAEMFAT ESLIFTDFKT AGKISESREL PDLGITQMRF ENGVRVNLKQ
     TDFSKDEIMV KISFGNGIFD IPADRPEYFA ALYALVLGGT KYQDASSVNA AKFLLKMDIN
     VGMDGNSFVM TGASTKKDFS QMVRLAATMF ADPGFREDGE ESLMKYGQGF YLDYETSPMS
     RIKFLPVELI ASPVARIPGT LKNFEKIKMK EIAEWLKPIL KNSYMEISIV GDFDKPEAIE
     LIKSTFGAMS AREPVKKDPM AVLKMKPLGE NFSITYRTVD EPRSIAAVMW QSCGRGDLVR
     MRAANVLGAV LDDVLRKDVR EKQGKVYSPF AYNNSSTWVK DFGLMYAMTF VVPSENADLV
     ETLKACGKKV AASISEDEFE RAKIPLLKGV EANKRKNEYW LSAVLNLSQA VPLNIELART
     IETGYSDVTL DEVRKLAREI FARPPYSASV VPYSGK
//