ID   R7MMJ9_9FIRM            Unreviewed;       840 AA.
AC   R7MMJ9;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II {ECO:0000313|EMBL:CDF01606.1};
GN   ORFNames=BN739_01369 {ECO:0000313|EMBL:CDF01606.1};
OS   Ruminococcus sp. CAG:624.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC   Ruminococcus.
OX   NCBI_TaxID=1262965 {ECO:0000313|EMBL:CDF01606.1, ECO:0000313|Proteomes:UP000017977};
RN   [1] {ECO:0000313|EMBL:CDF01606.1, ECO:0000313|Proteomes:UP000017977}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:624 {ECO:0000313|Proteomes:UP000017977};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDF01606.1}.
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DR   EMBL; CBKC010000251; CDF01606.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7MMJ9; -.
DR   STRING; 1262965.BN739_01369; -.
DR   Proteomes; UP000017977; Unassembled WGS sequence.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   InterPro; IPR013022; Xyl_isomerase-like_TIM-brl.
DR   PANTHER; PTHR43201; ACYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR43201:SF5; MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF01261; AP_endonuc_2; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF51658; Xylose isomerase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:CDF01606.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017977}.
FT   DOMAIN          21..244
FT                   /note="Xylose isomerase-like TIM barrel"
FT                   /evidence="ECO:0000259|Pfam:PF01261"
FT   DOMAIN          301..689
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          740..815
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   840 AA;  94987 MW;  7733F6DA844E1FBA CRC64;
     MKLSFSTLAC PDFEWTDIYS IAKDFHFDGI EIRGLGSDIF SVKAKPFTDL QLPNTVAKLK
     SLNLEIPCLS TGICLKFKEK AADNEEKLIE YAKLAQKLGT PYIRILADLE PHPIDEVDDA
     YIIETLKNLI PIAEKYNVTL LVETNGVYAD TKRLRKILDS VANRKVAALW DMHHPYRFMN
     ESPKQTVENL GEYIKYVHTK DSISVNGKIE YKLMGEGDMP VLDMLSALKD IGYNGYVSLE
     WVKRWSNNLC DAGVVIPHFA NFMSAYKSRH KHPLQDNIRK TGKYVWPKER LLDYTFPDIL
     DRICEEFPNQ YAFRYTELDY TRTYPEFRDD VDNLARALLA IGVKKGDHVA IWATNVPAWY
     ITFWATTKIG AVLVTVNTAY KIHEAEYLLK QSDTHTLVMI EGLKDSHYSE IIREICPELD
     SCPKGELNSK RLPVLKNIIT VGFEMKGCYT WDEVNGKAKE IPYSEVEKVR RTIDKHDVCN
     MQYTSGTTGF PKGVMLTHYN VVNNGKAIGD CMDLSTADRM MIQVPMFHCF GMVLAMTASV
     THGVTMSPIT AFSPRKGLAC INQEKITCFH GVPTMFIAML GHENFATTDF SYMRTGIMAG
     SPCPIKTMNE VIEKMNMSEI CITYGQTEAS PATTMSKTSD SIETRVNTVG GPIFGVECKI
     VDPETNEDLP DNVDGEFVAR GYNIMKGYYK MPEATAAAID SDGWLHTGDL ARRLPDGNFK
     ITGRIKDMII RGGENIYPKE IEDFIYTHPK VKDVQVIGVP DQDYGEEIMA CIILNPGETS
     TEDEMKQFVR DHMAKHKVPR YVDFVTEFPM NAAGKILKYK MRESAVEKFG LHKANKIVTA
//