ID   R7Q3C3_9EURY            Unreviewed;       315 AA.
AC   R7Q3C3;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Thiamine pyrophosphate protein domain protein TPP-binding protein {ECO:0000313|EMBL:CDF31501.1};
GN   ORFNames=BN463_00093 {ECO:0000313|EMBL:CDF31501.1};
OS   Methanoculleus sp. CAG:1088.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanomicrobiaceae; Methanoculleus.
OX   NCBI_TaxID=1262903 {ECO:0000313|EMBL:CDF31501.1, ECO:0000313|Proteomes:UP000018376};
RN   [1] {ECO:0000313|EMBL:CDF31501.1, ECO:0000313|Proteomes:UP000018376}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MGS:1088 {ECO:0000313|Proteomes:UP000018376};
RA   Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA   Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA   Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA   Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA   Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA   Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA   Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA   Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA   Wang J., Brunak S., Ehrlich S.D.;
RT   "Dependencies among metagenomic species, viruses, plasmids and units of
RT   genetic variation.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one gamma
CC       chain. {ECO:0000256|ARBA:ARBA00011595}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CDF31501.1}.
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DR   EMBL; CBKQ010000065; CDF31501.1; -; Genomic_DNA.
DR   AlphaFoldDB; R7Q3C3; -.
DR   Proteomes; UP000018376; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd03376; TPP_PFOR_porB_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR42897; PYRUVATE SYNTHASE SUBUNIT PORB; 1.
DR   PANTHER; PTHR42897:SF2; PYRUVATE SYNTHASE SUBUNIT PORB; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          49..215
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   315 AA;  34584 MW;  5286F52979D2D6D0 CRC64;
     MSGLSLKELN KIPVRLASGH RLCAGCAESI IARQILMGTE KDVAVSVSTG CFEVSTTIFP
     YTSWNIPMVH TAFGNGAAGA AGLETAYKSL KRQGKIDKDI KFVNFAGDGA TYDIGLQALS
     GAMERGHDMM FVCFNNEAYM NTGIQRSSAT EKGASTTTSW NGAESYGKKE YPKDMTAVMV
     AHNIPYVAQT APYAWRDMVT KARKAFECGG PSFINAISPC PRGWRFAPSD TIAISKLAVD
     CCVWPLYEVV DGEYSLSADS LRIADGKVEK KPITDWFDSQ GRFKHLKDER WAPVVEEIQK
     DVDKKWEKLL KLCGL
//