ID R7R3S0_9FIRM Unreviewed; 496 AA.
AC R7R3S0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Threonine synthase {ECO:0000313|EMBL:CDF44718.1};
GN ORFNames=BN450_01345 {ECO:0000313|EMBL:CDF44718.1};
OS Roseburia sp. CAG:100.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX NCBI_TaxID=1262940 {ECO:0000313|EMBL:CDF44718.1, ECO:0000313|Proteomes:UP000018092};
RN [1] {ECO:0000313|EMBL:CDF44718.1, ECO:0000313|Proteomes:UP000018092}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGS:100 {ECO:0000313|Proteomes:UP000018092};
RA Nielsen H.B., Almeida M., Juncker A.S., Rasmussen S., Li J., Sunagawa S.,
RA Plichta D., Gautier L., Le Chatelier E., Peletier E., Bonde I., Nielsen T.,
RA Manichanh C., Arumugam M., Batto J., Santos M.B.Q.D., Blom N., Borruel N.,
RA Burgdorf K.S., Boumezbeur F., Casellas F., Dore J., Guarner F., Hansen T.,
RA Hildebrand F., Kaas R.S., Kennedy S., Kristiansen K., Kultima J.R.,
RA Leonard P., Levenez F., Lund O., Moumen B., Le Paslier D., Pons N.,
RA Pedersen O., Prifti E., Qin J., Raes J., Tap J., Tims S., Ussery D.W.,
RA Yamada T., MetaHit consortium, Renault P., Sicheritz-Ponten T., Bork P.,
RA Wang J., Brunak S., Ehrlich S.D.;
RT "Dependencies among metagenomic species, viruses, plasmids and units of
RT genetic variation.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR604450-51};
CC -!- SIMILARITY: Belongs to the threonine synthase family.
CC {ECO:0000256|ARBA:ARBA00005517}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDF44718.1}.
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DR EMBL; CBKV010000092; CDF44718.1; -; Genomic_DNA.
DR AlphaFoldDB; R7R3S0; -.
DR Proteomes; UP000018092; Unassembled WGS sequence.
DR CDD; cd01560; Thr-synth_2; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR43515; THREONINE SYNTHASE-LIKE 1; 1.
DR PANTHER; PTHR43515:SF1; THREONINE SYNTHASE-LIKE 1; 1.
DR Pfam; PF00291; PALP; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR604450-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000018092}.
FT DOMAIN 5..80
FT /note="Threonine synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14821"
FT DOMAIN 101..421
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT MOD_RES 112
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ SEQUENCE 496 AA; 54952 MW; 82B8E40A87DDC068 CRC64;
MDLFYRSTRS KDERVTASQA ILQGLAQDGG LFVPESVPKL DKSLEELSKM NYQETAYEVM
KLFLTDFTKE ELQACISKAY DSKFDTEVIA PLVEADGAYY LELFHGATIA FKDMALSILP
HLLTTSAKKN NVHNEIVILT ATSGDTGKAA LAGFADVKGT RIIVFYPKHG VSPIQEKQMV
TQKGDNTFVV GITGNFDDAQ TGVKKLFGDK ELAQTMDQAG FQFSSANSIN IGRLVPQIVY
YVYAYAQLLK EGQIKENEVI NVVVPTGNFG NILAAYFAKN MGIPIGKLIC ASNENKVLYD
FFETGVYDRN REFVLTSSPS MDILISSNLE RLIYLTAGRD AQKNAELMQE LSKDGKYEIT
SEMKDNMKDF YGNYASEGET AQTIKDLYEK TGYVIDTHTA VAATVLHKYR KATGDETKAV
VASTASPFKF TRSVMDAIDK AKYDSMSDFE LVDELSRIAN VTVPNAIEEI RTAPVLHDTV
CDKEDMKAVV MKFLGI
//
