ID R7SJB1_DICSQ Unreviewed; 352 AA.
AC R7SJB1;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Delta-sterol C-methyltransferase {ECO:0000313|EMBL:EJF55805.1};
GN ORFNames=DICSQDRAFT_141756 {ECO:0000313|EMBL:EJF55805.1};
OS Dichomitus squalens (strain LYAD-421) (Western red white-rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Polyporaceae; Dichomitus.
OX NCBI_TaxID=732165 {ECO:0000313|EMBL:EJF55805.1, ECO:0000313|Proteomes:UP000053319};
RN [1] {ECO:0000313|EMBL:EJF55805.1, ECO:0000313|Proteomes:UP000053319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LYAD-421 SS1 {ECO:0000313|EMBL:EJF55805.1,
RC ECO:0000313|Proteomes:UP000053319};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Erg6/SMT family. {ECO:0000256|ARBA:ARBA00038188,
CC ECO:0000256|PROSITE-ProRule:PRU01022}.
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DR EMBL; JH719497; EJF55805.1; -; Genomic_DNA.
DR RefSeq; XP_007371455.1; XM_007371393.1.
DR AlphaFoldDB; R7SJB1; -.
DR GeneID; 18836211; -.
DR KEGG; dsq:DICSQDRAFT_141756; -.
DR HOGENOM; CLU_039068_5_3_1; -.
DR OMA; NGIATMM; -.
DR OrthoDB; 275921at2759; -.
DR Proteomes; UP000053319; Unassembled WGS sequence.
DR GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1901617; P:organic hydroxy compound biosynthetic process; IEA:UniProt.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR030384; MeTrfase_SMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR013705; Sterol_MeTrfase_C.
DR PANTHER; PTHR44068:SF1; HYPOTHETICAL LOC100005854; 1.
DR PANTHER; PTHR44068; ZGC:194242; 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR Pfam; PF08498; Sterol_MT_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01022,
KW ECO:0000313|EMBL:EJF55805.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053319};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01022};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01022}.
FT DOMAIN 53..350
FT /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT /evidence="ECO:0000259|PROSITE:PS51685"
SQ SEQUENCE 352 AA; 39723 MW; 7BCF497942CD3E26 CRC64;
MAPSATETTA HADGRVGRRI ENYTQFWQKD ISKEASHDTE NRLENYVDVI NGYYDGATGL
YEYGWGTSFH FSRYYKGEGF YQALARHEHY LAFKMNLKPG MRVLDVGCGI GGPAREIAQF
ADVNIVGLNN NEFQVGRARM MTAKAGLSDR ISYTVGDFMK LSEQFGENSF DAVYAIEATV
HAPSWEGVYG EILKVLKPGG VFGVYEWCMT DKWNPSIPAH KEVAHGIEIG NGIPEMRPLA
MARQAILDVG FQIEHEEDLA DRPDPIPWYY PLEGDIRKAQ TLWDMFTVWR MSSSGKFVTH
HGLWFIEKLG IVPKGTWEVG ETLKIAADAL VKSGREKLFT PMYLVVSRKP QN
//
