ID R7T8B0_CAPTE Unreviewed; 646 AA.
AC R7T8B0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 13-SEP-2023, entry version 40.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=CAPTEDRAFT_193667 {ECO:0000313|EMBL:ELT89678.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT89678.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT89678.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT89678.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP193667}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQN01003209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB311229; ELT89678.1; -; Genomic_DNA.
DR AlphaFoldDB; R7T8B0; -.
DR STRING; 283909.R7T8B0; -.
DR EnsemblMetazoa; CapteT193667; CapteP193667; CapteG193667.
DR HOGENOM; CLU_424052_0_0_1; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0032481; P:positive regulation of type I interferon production; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.5.5200; -; 1.
DR Gene3D; 3.40.50.12100; Stimulator of interferon genes protein; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR029158; STING.
DR InterPro; IPR038623; STING_C_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR34339; STIMULATOR OF INTERFERON GENES PROTEIN; 1.
DR PANTHER; PTHR34339:SF1; STIMULATOR OF INTERFERON GENES PROTEIN; 1.
DR Pfam; PF13676; TIR_2; 1.
DR Pfam; PF15009; TMEM173; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760}.
FT DOMAIN 193..318
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 612..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 646 AA; 73209 MW; 626CDB0792580978 CRC64;
MPYVRRKHDP ESCIFMSEVW GQAYDCVYVK REVAVPCFAH NRFIFNCYLL GPMPSYFHTM
YSETERCLFL HVFHVCMFQC GMADSVADKG GGEDGSPDLL GLSEETENSD DVDCSDELIE
AVEKEVQNLT DVLRRNLDSA KKKKNLLQVQ QFRTKIKQCA AHSNVGASHP ITGKSTYDKK
LDEGYAVPSL NGYEYHVTVF GSDDDLKCSR EVVEKLKDKG FKVFSFDNIL PNESTVKKTM
AAFRKSRKVV ALISQKFIQS PMHYEIYVAC HEMKERQRAF LIPLLTGVGE CEVPSYVRTV
NSVSMSDELW LRKLIEVMND ERPLSTLIPT GDVANGLAWS YFYGYMKIIL PGLRERVDKH
VKGDELTNCL KDKNEDINLQ KDETFLKKFI CILPMTSVCP NNFDEADENI LTIGSVEYSS
TISGNVKRNY KTCIHRVQHP EDKSKKFLFM GEFATPLRSL DKMYEGGIAG LTLKERNRQT
SIFQMKLKEV MCHPAAEDCM DYFVHLIYKG IEKYVQGTGF FDEEVFEESE QSVMLKYKGV
VWTLKTLRRR GVFELSVFEL AGFHCTSLLG IKCDPVEFSL DVDGKSADGS VKKADNLALL
LCETIEREMA AESSKKKAEQ DAAAQPKDAE AEPKCDDAGN CGVSEE
//
