ID R7TI41_CAPTE Unreviewed; 680 AA.
AC R7TI41;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=CARD domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_201959 {ECO:0000313|EMBL:ELT93384.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT93384.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT93384.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT93384.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP201959}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQN01029837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB309771; ELT93384.1; -; Genomic_DNA.
DR AlphaFoldDB; R7TI41; -.
DR STRING; 283909.R7TI41; -.
DR EnsemblMetazoa; CapteT201959; CapteP201959; CapteG201959.
DR HOGENOM; CLU_009460_3_0_1; -.
DR OMA; IARQENQ; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46844; SLR5058 PROTEIN; 1.
DR PANTHER; PTHR46844:SF1; SLR5058 PROTEIN; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF05729; NACHT; 1.
DR SMART; SM00114; CARD; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 67..161
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 242..364
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 78670 MW; C344DBF5C8AAA0FC CRC64;
MTGAQSTRRH MMSTASKNAA NQHNILERSF ADVTTDAEKE LLSTELNYST RASEKPLEQA
KSVEFKMEDR HKECLKSNRD YLLSEISLSA VLLAKLSESG VITDEHLQKL QNTERKDTTK
AAVLEFLSEV LPKRGPEAFN LFLKALSESE QRHVAERLKQ CLSDVCPEDA GTFERLRSEL
QSYYKRKLAS ICPMPWLQSI YLNLTDVFVE RQLKLKTNYK GDERIVTMDD IFTPQQTREI
PRRLLIEGNP GIGKSTICQT LAHEWGEQSC GRHCGTLCVH SFDLVLYFHA GDFIDEESVA
HAVREHLLPS DYSITTSELQ GVIKAKNVLI IVDAFDEANA GNRTLDRLIE GDILRHKTLL
ITSRFNFLEN KLRHFESRFT VEGYDEEERL QHVERYAEHK RIDPKPFISM LEEESIRDLC
SNPLNLTLLC LLREEDTQLM TTRTALYTSI HRIIKQKAAK RLKLIEAEVE ESLLRPLYQF
AFEAHRKNET VVREKDSKKV KNFQRICQVG YLTNEVIISR LQKEVRFQFT HKTFVEFLTA
KHIAEMDREE RMNWMQHLRY ANCYIRIKGL AIDDYFKVEQ NEAILGFLFG LLEEESAELT
QMASLVIKET HFSSEHHHPI SSDPLSLYSR CGASHQLLRL IAELNVVPQE LADVICERRP
PFINIHPSNS HERPFGIFTR
//
