ID R7TST9_CAPTE Unreviewed; 2338 AA.
AC R7TST9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Spectrin beta chain {ECO:0000256|PIRNR:PIRNR002297};
GN ORFNames=CAPTEDRAFT_148581 {ECO:0000313|EMBL:ELT96714.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT96714.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT96714.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT96714.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP148581}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the spectrin family.
CC {ECO:0000256|ARBA:ARBA00006826, ECO:0000256|PIRNR:PIRNR002297}.
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DR EMBL; AMQN01011188; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB308745; ELT96714.1; -; Genomic_DNA.
DR STRING; 283909.R7TST9; -.
DR EnsemblMetazoa; CapteT148581; CapteP148581; CapteG148581.
DR HOGENOM; CLU_000146_1_0_1; -.
DR OMA; DNHEPWI; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProt.
DR GO; GO:0008091; C:spectrin; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:UniProtKB-UniRule.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-UniRule.
DR CDD; cd21246; CH_SPTB-like_rpt1; 1.
DR CDD; cd21248; CH_SPTB_like_rpt2; 1.
DR CDD; cd10571; PH_beta_spectrin; 1.
DR CDD; cd00176; SPEC; 8.
DR Gene3D; 1.20.58.60; -; 11.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR016343; Spectrin_bsu.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF447; SPECTRIN BETA CHAIN; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF00435; Spectrin; 17.
DR PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00033; CH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00150; SPEC; 17.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 13.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203,
KW ECO:0000256|PIRNR:PIRNR002297}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR002297};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212,
KW ECO:0000256|PIRNR:PIRNR002297};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 24..128
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 143..248
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 2193..2305
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 2061..2082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2116..2214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2308..2338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 427..461
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 753..787
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 965..999
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1217..1248
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1290..1317
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1396..1423
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2061..2077
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2165..2179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2197..2214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2338 AA; 271043 MW; C23DA6C240515F8A CRC64;
MEEGNPAKLF ERSRIKALAD ERESVQKKTF TKWVNSHLSR VGCRIQDLYV DLRDGKMLIK
LLEVLSGERL PRPTKGKMRI HCLENVDKSL SFLLEQRVHL ENMGAHDIVD GNPRLTLGLI
WTIILRFQIQ DITIEETTSR EVKSAKDALL LWCQMKTAGY ANVNVRNFTT SWRDGLAFNA
LIHKHRSDLI EYNQLTKANP NYNLNNAFNV AEEKLGLTRL LDAEDVSTEY PDEKSIITYV
VTYYHYFSKM KAESVQGRRV GKVVNQCLEH DHMIADYDSL TSELLDWIEN TIEVLNDRQF
ANSLNGVQQQ LAAFNTYRTV EKPPRFVEKG NLEVQLFTIQ SKMRANNQKP YLPAEGKMIS
DINRAWDRLE KSEHGRELAL REELIRQEKL EQLAARFDRK AGMRETWLSE NQRLVSQDNF
GYDLAAVEAA TKKHEAIETD INAYEERVQA VISVANELEQ ENYHDIDRIN ARKDNVLRLW
NYLLELLRAR RMRLELSLQL QKIFQEMLYI LDWMDEIKAR LQSEDYGKHL MGVEDLLQKH
SLLESDIHIV GERVKTVNGN AGRFHEADFP DVAGYKPCDP EVVKDRMSHL DAAYEELLAL
AADRRARLHE SRKLWQFYWD MADEEGWIKE KEQLMASPDL GHDLTSVHLL LKKHKANEDE
LQARHSHLND VLKVGDDLIK ADNFGKEKIQ DRTDEINSQW ANLTELSNYR RKRLAEAVDF
YQFFTDADDV DTWMLDILRL VSSEDVGRDE ASVQSLLKKH KDTTDELQNY QSVIQALHEQ
AASLGEQDRE SPEVQGRLGS IDRRYQELLE LAKIRKQRLL DALALYKLYN EADGVEQWIT
EKEKLLHTML ATDDVEEVEI LKARFDTFDQ EMNANADKVE TVKQLSRQLV HNEHPNSDEV
LSRESDVNDK WDKLRSLADG KKGSLNLAHD VNTWHIECQE TMTWIREKAK LIESTDDLGN
DLGGVITLQR RLSGLERDLA AIQAKLDSLQ GEADRLADEK PEEAEAIQVK VTQITELWQE
LKTMLKVRDE RLGEANELQK FLADLDHFQQ WLTRTQTTIA REDFPQDMAE AEQMLNEHKA
IKEEMEAYES DYAKMKEFGE KTVEGQEDVQ YMFLRERLKA LDDGWEDIHK MWQNKQHLLS
QGLNLQMFMR DAKQAEVLLS QQDNFLSKEE VPHSLEHSEN LIKQHEAFIT TLDANDEKVN
NVLSFSQRLI DENHFAQDKI AQKAENLKDR RQQNRQRAYD QLQKLKDSLK MQQFLQDCDE
LSDWLGEKTI AAQDETYRDA KNIHSKYMRH QAFESEIKSN KDRLDKLIQE GEALQEEKPH
MAEVVEPKLE ELRKQWDELE NITKQKGQRL FDANRHILYE QNCDDIDGWI TTIESCIEAD
DTGHDLTTVN LLVQKQNILE SELKIKQQQV AELESQKDHL NDVEPEKEEV IRAKKVQVEE
RFVKMLEPLQ ERRSKLERAK RLQQFLRDLE DEKLWISEKM PQSTSTNFGN NLLGVQMLQR
RNKSLRNEID GHEPQHTHIM DLGKELIDEG HPQAEEFQQS LDELEKAWQD LLDSVEHRRK
MLGLSEVAQQ YLFDASESEA WMSEQELYMM AEERAKDEVG ANNMLKKHST LEKTVEDYAD
TIRELGDRSR ALIDEAHPDS DQVAVKQSQV DKLYASLKDL AGERRGKLDE VLKLYILNRE
IEDIEQWIAE REVVAGSHEL GQDYEHVTML RDRFKDFAQE TETIGQERVS IVNDNCDALI
EAGHSDAATI AEWKDQINEM WADLLELIDT RMEMLAASWK LHKFFHDCKE TLERIYEKQN
TIPDELGRDA QTVAALQRRH ASFEHDLVTL GSQVQQVQEE AATLIVAYSG DRAQDIQDKE
AEVVNAWRNL QINVERRKIL LADSSDLFRF FGMVRDLMNW MNDMTRQMST QEKPRDVSGV
ELLMNNHQSL KAEIDARDEN FTICVNLGKD LLARKHSRSQ EVRERLIQLG TQRGGMMEQW
EDRWEHLRLI LEVYQFARDA SVAETWLMAH EPYVQSHDYG DTIDIIEAMI KKHEAFERSA
MTQEERFAAL ERLTTFELRE RQKQQEEEFR REHPDAPLPQ KTSFAERYIE EFLPPPEPEP
EPEPTPAPVV ETLAPKAESP VKAKEAETQQ AEDGRPQSAV VMRSKDAIDS PQRHVLSEPG
SPDGGDRGKA VHRSASADRG KQRASPTAGP SGDDSFEGQL VRKHEWESTT KKASNRSWDK
VFCVLTAKAL ASFKDQKHAK SEPKTYFHNE QPIDLDGASA AKASDYQKRP HVFRLKLGNG
GDYLYQCKDD DEMTSWINRI NVAVGSEGGA ASGRAQTLPA PGQRDEPKRR SFFTMKKK
//
