ID R7TSU0_CAPTE Unreviewed; 844 AA.
AC R7TSU0;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Histone-lysine N-methyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_153177 {ECO:0000313|EMBL:ELT96958.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELT96958.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELT96958.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELT96958.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP153177}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AMQN01011142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB308715; ELT96958.1; -; Genomic_DNA.
DR AlphaFoldDB; R7TSU0; -.
DR STRING; 283909.R7TSU0; -.
DR EnsemblMetazoa; CapteT153177; CapteP153177; CapteG153177.
DR HOGENOM; CLU_000065_1_0_1; -.
DR OMA; SCKNHAP; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0043933; P:protein-containing complex organization; IEA:UniProt.
DR CDD; cd15666; ePHD2_KMT2C_like; 1.
DR CDD; cd19171; SET_KMT2C_2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR PANTHER; PTHR45888:SF6; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 328..440
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 704..820
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 828..844
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 220..247
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 844 AA; 95735 MW; ACFF998F6EEE1CA5 CRC64;
MSRASDQSPA TIISSSSPEC AQLADVRPHN PLLPLTGLRL ISEDSQDSSL LRSDCQSPEI
DVIKPVPIKV QPKDEPDLQQ PKMEPLVAVE PMRENQLSVT LTMSSRAAED IGGVLNAIAD
LLKIAVPPSF EVSRSPSPDL FSFARHAAAR HMEEKVDLQT LIKSRMKFCR HCDVAVMTGV
RKKKSDIPYL GKEEFVNKDD EMMFCSEDCY EQFATAHRHA RESQMAREEL NAQIEALRLK
QLQLLAAQTQ SPEPMAEKLR LRRASSLTVE PKYPPITERK WAGLKYKKWD ATMMKVGHVA
PPPTEQELLQ LMTKLGQTIR CVPDIVDKRT CVLCHVTGDV ETDGPGRLLH LSAEGSGDKW
VHLNCALWSY EVYETMNGSL VNVDQACKRG ASLQCVVCSQ SGATVGCFKL RCTNAYHVRC
AQAEGVIFFQ DKTILCPQHT PKLPENVLPS LAVFRRVYVS REEDKQIASF VHQEEKNSVI
RVGSLIVYNV GQLLPTQMHS GIFNTRDYIY PVGFHSCRFY WSSKRVHRRC RYICCIDEND
NRPEFSVTVK ERGHEDVTFK GDTCSGVWQS LLENLSRMRL DLDLVKMFPL YLSGEDLFGL
TDSNVVRMLE SLPGIELITN YTFRYGRSPL FELPLAINPT GSARSEPKLR TPFKRPHTLH
GSSNTRSIPA TVTLVPGDST MPYMKQFVHS KSQQYRRLKT EWRINVYLRR SNVQGLGLFA
SRDLERHTMV IEYIGELIRS EVAEARERVY DSQNRGVYMF RIDDNTVVDA TMTGGPARYI
NHSCAPNCVA EVVPFEKDSK IIIIARRRIA RGEELTYDYK FDFEDDQHKI PCLCGAPNCR
KWMN
//
