ID R7UHN8_CAPTE Unreviewed; 773 AA.
AC R7UHN8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Ionotropic glutamate receptor L-glutamate and glycine-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_188571 {ECO:0000313|EMBL:ELU06044.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU06044.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU06044.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU06044.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP188571}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMQN01007607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB300985; ELU06044.1; -; Genomic_DNA.
DR AlphaFoldDB; R7UHN8; -.
DR STRING; 283909.R7UHN8; -.
DR EnsemblMetazoa; CapteT188571; CapteP188571; CapteG188571.
DR HOGENOM; CLU_007257_10_0_1; -.
DR OMA; ALENAWF; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR42643; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR PANTHER; PTHR42643:SF13; IONOTROPIC RECEPTOR 20A-RELATED; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 546..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..754
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 351..710
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 361..421
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 773 AA; 87371 MW; 507A23B8BC545C3D CRC64;
MRFLAPREKH PGVLTDEGSE DAQLLEAMDN LLSHSPFNVS VHFVTITDNS FRLYLDVCSA
ASKGVATFIS LASCDLQYTL QSLSMDIRIP LIQVNSDCPD NIQLDSNVDY LHRYPAAPVD
LEVVLLGILD ELGWSDLVLI TDEIQDENLL NSINSACRKG NVTAQHFKIT DDSRRSDVTS
VLDFVAEEVS KEQFLVACGF PCIKELFRQA NSYSYDGRIE NHALFTFETS YVLIVMNDSM
IYDITMEARD IDNVLLINPA QRNISHYHAM KALGHVVNTL LAINDSYTRF EIQLNTSSCN
SCPIYEVNSL QWGPGRERKL ELVAEWQEYK GMAKIQETLM VNKLRGFNGR TFRIGTNLWN
PFVLENHTSA SVQGYGGLSI ELLKELSNNL NFSFTLHFPE DNGWGSYVNG SWTGLVGMLV
NKEVDMVVAS LSRTPAREMV VDFTAPYYLD HCTVLVKYPD LEDKKWKLFI NPFRWQVWLV
LAGVIPFSGL ILWTLSRYSP YYSKEQAFAG LGLLDNAVFY TFGAFFTQGG CHLPDAQSGR
FFTGFYWMAC IVIVATYGGN LIAFLTVSKD VLPFDFFEEM VNQDEYKYGI LNGTALTDYI
DMASDSTMKQ LKRNLDSMAK EDSTIYSKNH STHITRVLKG GYGYIGDMTS FEVEMSNACD
IDMIRETISP YEYSVALWEN SAYRPLVNDE VSMIKESGLV KKWKADWWPR QSFCSRGLVT
EAKAVSMDDV QGAYYLMAIL LVVSFVALVA EGFWQKHNMN HKVNEAPGKE SSI
//
