ID R7UIP5_CAPTE Unreviewed; 1041 AA.
AC R7UIP5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CAPTEDRAFT_209081 {ECO:0000313|EMBL:ELU03668.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU03668.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU03668.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU03668.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP209081}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQN01024393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01024394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQN01024395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB302989; ELU03668.1; -; Genomic_DNA.
DR AlphaFoldDB; R7UIP5; -.
DR EnsemblMetazoa; CapteT209081; CapteP209081; CapteG209081.
DR HOGENOM; CLU_009460_2_1_1; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46844; SLR5058 PROTEIN; 1.
DR PANTHER; PTHR46844:SF1; SLR5058 PROTEIN; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF05729; NACHT; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 74..141
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 236..359
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1041 AA; 118662 MW; 913952915B26A692 CRC64;
MIHSVIFSVR LLNCLPAENE QRCNPELYGD SFFLTLLSKS DTQLDSIYIS WVKVANDYVK
KFLSTNPRST STAKITTKEL HGLWSQMLSC NIITKSDKDL IMRDKTPQQQ VGALLDHLEN
RTERDYEAFC ECLKRDNQEH VVTDILCSEA QVPASNKSDV RQQLERRYNH LEFIQTAPEW
APKLALDSTI FYISLHLQID ETSTTQKEEF SQDEVFVPHR KQKTRPGMTL EPCNPKRILV
EGDPGMGKST LCRNLAFRWA REKCTGECKY TPCVHSWSLV IYLTAANIQG YDDIETAVRA
HLLPRMTIDE VKDALNSNQS TVLFIVDSFD EGNNDNPILR DLIKGHVYAN ATLLLTSRPH
SLKELEMREF ESKLSTQGFN NEQKRFSPLN LAIICLLISE GLPSMATRTE LYESVTKFLV
KKASDRMGRP KEEIEEDIIR PLCRLSFEAY KRNEVCLSNE DLEKDGVNAD DVLRSGFLTK
EVKVSLIDDR VERLSFSHKT FLEYLAATHL VQIPGDLKDW LKTAAADWQH HYSLKSFFFD
LLHGYSLVEA SLVMMDIFAF SHEKGVVYNL PGSCLLLNVL RHLKEKTIIL APENENELKE
KCRSIIDRTV ECSLEPESFC CIEIIFATVS QSGESLNKSM NVVSEAKHVF DYLRNSEKCT
NVNLRIECAD ESVANKSSIP QQGGHHSSFF SYAADRLTSG NIPLASDDDP NDLLRIALEP
GFGNDIRGMA FEELKGKKKR TGIKGGLNSF LRAALDKPLT KLKIDSSGSM DIECGKMIVD
LCSNSQLKVL YIRSFFVNDY RMQLLSKLSS LGALDELYVN FSMDNMDSHE ICLYEQILKK
NKMRELEICG HGISNELWSV FLSTIPTMSA LKRLKIQDER FDFCSYDIWK SANDQLNLQS
FTLRSLSLTS ESFDNLCDLL VKWTQLRKLK IKKIEIAGER PKSNHSAKII AAIAKCEMLE
ELHLSFVDII DDVMDQFCEA VTQNYTYLPS HTTNSHRLPQ CTVEGRIVRG TATINMDWME
GSLRIRSLLP SSLRRPQSRE E
//
