ID R7VHH9_CAPTE Unreviewed; 1076 AA.
AC R7VHH9;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ELU18032.1, ECO:0000313|EnsemblMetazoa:CapteP222780};
GN ORFNames=CAPTEDRAFT_222780 {ECO:0000313|EMBL:ELU18032.1};
OS Capitella teleta (Polychaete worm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Sedentaria; Scolecida; Capitellidae; Capitella.
OX NCBI_TaxID=283909 {ECO:0000313|EMBL:ELU18032.1};
RN [1] {ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|Proteomes:UP000014760};
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ELU18032.1, ECO:0000313|Proteomes:UP000014760}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I ESC-2004 {ECO:0000313|EMBL:ELU18032.1,
RC ECO:0000313|Proteomes:UP000014760};
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:CapteP222780}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR EMBL; AMQN01003891; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB292163; ELU18032.1; -; Genomic_DNA.
DR AlphaFoldDB; R7VHH9; -.
DR STRING; 283909.R7VHH9; -.
DR EnsemblMetazoa; CapteT222780; CapteP222780; CapteG222780.
DR HOGENOM; CLU_004111_1_1_1; -.
DR OMA; HYINRTV; -.
DR Proteomes; UP000014760; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF122; INTEGRIN ALPHA-PS1; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000014760};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1020..1042
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 133..185
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 256..315
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 328..384
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 388..452
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 437..603
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 605..738
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 754..993
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1076 AA; 120208 MW; 525581E37EE1BC06 CRC64;
MEVCYRSNRH PTGDPACSVI VGAPKDNITD PSALPQVRDV VRPGQVYSCP LSSFSDDCVA
LAIDREAPNS NEDKTDMWFG VSVASQRTPD GMAVACGHRY KEVGSTFRWG MGMCISLSNA
LDGDQFWNPC GGLSTAGGHT EYGFCQSGSS VAVNADGDIA FGIPGPYVWR GAVLKNRIVQ
SLTEFQENYW SPVESLDEHE IGPEPATDYY SYLGMSAKIG RVNNKTMYIG GAPRSKDLGQ
VLMFSQDTAN RRLKISDDNY LTGEQFGSNF GHDFAVVDLN NDKNEDIVVG APFYYEKGIG
GAIYVFISGP KGVTSDTVPI KIYSRSMNTS ECTLLDCENA RFGFSIANIG DVDKDGFQDI
AVGAPYEGNG AVYIFRGAAS GIVKEYSQRI YADDLQTARE MRTFGYSLSG GIDMDNNFYP
DLAVGAYESA KLVILRSRPV ININAVVLSI PEKLKHDMKR CATTGLEWGC FEIRTCFKYS
AEPKDRFTDR LTIEYKLEAE RFTGLKRSRV FFEGKSQTEG YVLEKQIKLN AQSDPLFKCR
QHTVYLNRNN RDFLNPIAFR LSYKLLDMVP PTMVPGMALP DINEYPVLNE KASSQVFLAQ
FEKNCGDDNI CRSNLHVKGF FHMDVDQNED YVLRVGEGNE LELFIQLSNN AEDAHEATLA
LEMPPHVFYK GINTNDKDLS CIPTGQRVSC QVGNPMKQHH QTEFSVRLEL EGVHSSMDIL
KFMLWLNTTS AEIDPVDDMD EVNVRIIVET DLLVRGFGLP GEVEYSGEVV GESAIRFEDE
IGLSITHIYE VKNVGLGVVS NSTVFINWPF ELASDYAHGK HLLYMMDFPE IQPPARCIVP
NDLVNPLGVI VSYNQDEMSH AFDSMSLVYL QRVEPPAAVY DPSNPDNSNI TFIEANARSK
RDSQSFSTES FQDANGREMK VVTLDCDNGG AKCIRFPCHI GRLSRTDRNS VSIKIHARLW
NSTFLEDFRD VDQVRIFSKA QIYIDPKLNV KQLNSANDVA SAMTLARPAL VVTAQKEVPL
WVIILSVCAG ILLLIILIII LWRCGFFKRS SHEEMTKHQA NLEKRDKKEP LNYYYD
//
