ID R7XWB7_9ACTN Unreviewed; 666 AA.
AC R7XWB7;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Short chain dehydrogenase {ECO:0000313|EMBL:EON23613.1};
GN ORFNames=CF8_2408 {ECO:0000313|EMBL:EON23613.1};
OS Nocardioides sp. CF8.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=110319 {ECO:0000313|EMBL:EON23613.1, ECO:0000313|Proteomes:UP000015971};
RN [1] {ECO:0000313|EMBL:EON23613.1, ECO:0000313|Proteomes:UP000015971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF8 {ECO:0000313|EMBL:EON23613.1,
RC ECO:0000313|Proteomes:UP000015971};
RX PubMed=23833136;
RA Kimbrel J.A., Chang J., Arp D.J., Sayavedra-Soto L.A.;
RT "The Draft Genome Sequence of Nocardioides sp. Strain CF8 Reveals the Scope
RT of Its Metabolic Capabilities.";
RL Genome Announc. 1:e00439-e00439(2013).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON23613.1}.
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DR EMBL; ASEP01000076; EON23613.1; -; Genomic_DNA.
DR RefSeq; WP_010833295.1; NZ_CM001852.1.
DR AlphaFoldDB; R7XWB7; -.
DR STRING; 110319.CF8_2408; -.
DR PATRIC; fig|110319.3.peg.3014; -.
DR eggNOG; COG0300; Bacteria.
DR eggNOG; COG3320; Bacteria.
DR HOGENOM; CLU_026975_0_0_11; -.
DR OrthoDB; 9810734at2; -.
DR Proteomes; UP000015971; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05263; MupV_like_SDR_e; 1.
DR CDD; cd05233; SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR44196; DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B; 1.
DR PANTHER; PTHR44196:SF5; POSSIBLE MULTI-FUNCTIONAL ENZYME WITH ACYL-COA-REDUCTASE ACTIVITY ACRA1; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000015971}.
FT DOMAIN 5..233
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
SQ SEQUENCE 666 AA; 72136 MW; 89151536DBAF4294 CRC64;
MSYFVTGATG FIGRHLVEEL LDHREGDVFV LVRPGSRGRI DALIRRWGTD RVIPVEGDLA
TPGLGVDPAW TAANTGKIDH FFHLAAIYDM TADDATNDAM NVDGTRHALA LAEEIGAGCF
HQVSSVAAAG DHRGTFDETM FAEGQHLPSP YHRTKYESEA IVRDESTVPW RVYRPAIVVG
HSETGAMDKV DGPYYFFPVL KLLRDNLPAW LPLVGVDLGD TNLVPVDYVA KAMDHLAHAP
GHDGEAFHLV NPEPQPVVET IGLFCAAAGA PRFATPIDRR ITASKLVPRP LRPSTMVGAL
VRSGPIQLLL DQTIGRAGIP AEVVGHTSFT AVFDSRRTEE ALAGSGIAVP DLESYARTLW
GYWEDNLDET TGRSSTNRAA LEGKHVVITG ASSGIGLVTA LKVAQCGGIP VLVARGKDKL
EETRALIEQR GGQAHVYPCD LSDLEAIDAL CTQMSAELPS IDFVINNAGR SIRRSLRLSY
DRFHDFERTM QLNYFGAIRL IMGLMPAMQR QKSGHIVNVS SIGVQTNPPR FAAYVASKAA
LDSWSNVVAS EVVGNGVTFT NIHMPLVRTP MIAPTKLYDK FPTISPAQAA DILIRAMVDR
PHEINTALGN VGAIAHTVAP KAAFRLLNMA YHVFPDSAAA KGETPDGGTR ESEQIMLAKV
FKGIHW
//
