ID R7XYP8_9ACTN Unreviewed; 944 AA.
AC R7XYP8;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=DNA primase {ECO:0000313|EMBL:EON24413.1};
GN ORFNames=CF8_1624 {ECO:0000313|EMBL:EON24413.1};
OS Nocardioides sp. CF8.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=110319 {ECO:0000313|EMBL:EON24413.1, ECO:0000313|Proteomes:UP000015971};
RN [1] {ECO:0000313|EMBL:EON24413.1, ECO:0000313|Proteomes:UP000015971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF8 {ECO:0000313|EMBL:EON24413.1,
RC ECO:0000313|Proteomes:UP000015971};
RX PubMed=23833136;
RA Kimbrel J.A., Chang J., Arp D.J., Sayavedra-Soto L.A.;
RT "The Draft Genome Sequence of Nocardioides sp. Strain CF8 Reveals the Scope
RT of Its Metabolic Capabilities.";
RL Genome Announc. 1:e00439-e00439(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EON24413.1}.
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DR EMBL; ASEP01000049; EON24413.1; -; Genomic_DNA.
DR AlphaFoldDB; R7XYP8; -.
DR STRING; 110319.CF8_1624; -.
DR PATRIC; fig|110319.3.peg.2213; -.
DR eggNOG; COG0358; Bacteria.
DR eggNOG; COG1372; Bacteria.
DR HOGENOM; CLU_013501_1_0_11; -.
DR OrthoDB; 9803773at2; -.
DR Proteomes; UP000015971; Chromosome.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003896; F:DNA primase activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR CDD; cd03364; TOPRIM_DnaG_primases; 1.
DR Gene3D; 3.40.1360.10; -; 1.
DR Gene3D; 3.90.980.10; DNA primase, catalytic core, N-terminal domain; 1.
DR Gene3D; 3.10.28.10; Homing endonucleases; 1.
DR Gene3D; 3.90.580.10; Zinc finger, CHC2-type domain; 2.
DR InterPro; IPR037068; DNA_primase_core_N_sf.
DR InterPro; IPR019475; DNA_primase_DnaB-bd.
DR InterPro; IPR006295; DNA_primase_DnaG.
DR InterPro; IPR013173; DNA_primase_DnaG_DnaB-bd_dom.
DR InterPro; IPR036977; DNA_primase_Znf_CHC2.
DR InterPro; IPR013264; DNAG_N.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR027434; Homing_endonucl.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR004860; LAGLIDADG_2.
DR InterPro; IPR034151; TOPRIM_DnaG_bac.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR002694; Znf_CHC2.
DR NCBIfam; TIGR01391; dnaG; 1.
DR PANTHER; PTHR30313; DNA PRIMASE; 1.
DR PANTHER; PTHR30313:SF2; DNA PRIMASE; 1.
DR Pfam; PF10410; DnaB_bind; 1.
DR Pfam; PF08278; DnaG_DnaB_bind; 1.
DR Pfam; PF08275; DNAG_N; 1.
DR Pfam; PF14528; LAGLIDADG_3; 1.
DR Pfam; PF13662; Toprim_4; 1.
DR Pfam; PF01807; zf-CHC2; 2.
DR SMART; SM00766; DnaG_DnaB_bind; 1.
DR SMART; SM00306; HintN; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SMART; SM00400; ZnF_CHCC; 2.
DR SUPFAM; SSF56731; DNA primase core; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF55608; Homing endonucleases; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 2.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 4: Predicted;
KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Primosome {ECO:0000256|ARBA:ARBA00022515};
KW Protein splicing {ECO:0000256|ARBA:ARBA00023000};
KW Reference proteome {ECO:0000313|Proteomes:UP000015971};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 575..663
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 752..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 944 AA; 103476 MW; 1E8B8593DBDF47BB CRC64;
MAGRIREDDI SEVREKARID DVVSGYVTLR KAGGGSLKGL CPFHDEKSPS FHVTPSRGFF
HCLAGETRVL TSEGIQEIRD LAGGIHRVLG ANAQWVDAPF KSYGVQRLHK ITVTRNQQVK
ELYATDGHRW FIRSGKGLKN SKELLTSDLK AGDTLVTKFP GSKIRRSRPS PFGVAHGFTF
GDGTRSGTGA MALLCPPKDA VMLKWFPQCH TSSSGPNLLV HDLPAFFKEL PSLTESVSYL
YGWLAGYFAA DGCVAADGTV ILNSAKKENL EFVRDVCTRL GIATYGITTQ SRVGFEGRDP
SDLHRVHLVS QDLQENFFLI DEHRERFVAT TKAYARRGWV VRSVEPTDRV EEVFCAEVPE
GHAFTLEDNI LTGNCFGCQE GGDVIAFLMK IDGLSFGETV ERLADKYGVQ LRREDGDGPP
ERPRGPARGR LIEANKIAQE FYAGQLETAD AVAARDFLTQ RGFDKDAAAT FGLGFAPRDG
EALARHLRGR GLTDEESIAA GLVASGRSVY DRFRGRLLWP IRDASGDTIG FGARRIFDDD
KIEAKYLNTS ETSIYKKSQV LYGIDLARRD MARSSQAVVV EGYTDVMACH LAGVPTAVAT
CGTAFGDDHA RVLRRFLHDH EEFRGEVIFT FDGDSAGQAA ALKAFNGDQN FVSQTYVAIE
PEGLDPCDLR IQKGDAAVRE LVAKRQPLYR FVLTNVASKY DLDRADGRID ALREAAGLVS
SIRDKSKVDA FAREIAGMLG VDVDDARSEV RRAAARASRS PADRRTPQAA HGSAEPAAPA
RPQVPSLRDP RFAIERETLK IVIQHPASVG RVINGVGPDD FSHPTYRGVW EAVAAAGGPA
AGVEDQGWST RVRSSVADPA VSSAISELGV EPVLTPSAPT ATYVAMHVYR LQELTTMRRI
AELKSRLQRT NPVEHAAAYN KMFGELVALE QYRRNLRDQQ VKTQ
//
