ID   R7ZQW6_9BACT            Unreviewed;      1004 AA.
AC   R7ZQW6;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=beta-N-acetylhexosaminidase {ECO:0000256|ARBA:ARBA00012663};
DE            EC=3.2.1.52 {ECO:0000256|ARBA:ARBA00012663};
GN   ORFNames=ADIS_2898 {ECO:0000313|EMBL:EON76448.1};
OS   Lunatimonas lonarensis.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae.
OX   NCBI_TaxID=1232681 {ECO:0000313|EMBL:EON76448.1, ECO:0000313|Proteomes:UP000013909};
RN   [1] {ECO:0000313|EMBL:EON76448.1, ECO:0000313|Proteomes:UP000013909}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AK24 {ECO:0000313|EMBL:EON76448.1,
RC   ECO:0000313|Proteomes:UP000013909};
RA   Singh A.;
RT   "A novel strain isolated from Lonar lake, Maharashtra, India.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC         residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC         Evidence={ECO:0000256|ARBA:ARBA00001231};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family.
CC       {ECO:0000256|ARBA:ARBA00005336}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EON76448.1}.
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DR   EMBL; AQHR01000085; EON76448.1; -; Genomic_DNA.
DR   RefSeq; WP_010855032.1; NZ_AQHR01000085.1.
DR   AlphaFoldDB; R7ZQW6; -.
DR   STRING; 1232681.ADIS_2898; -.
DR   PATRIC; fig|1288963.3.peg.2886; -.
DR   Proteomes; UP000013909; Unassembled WGS sequence.
DR   GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.40.50.1700; Glycoside hydrolase family 3 C-terminal domain; 1.
DR   Gene3D; 3.20.20.300; Glycoside hydrolase, family 3, N-terminal domain; 1.
DR   InterPro; IPR001466; Beta-lactam-related.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR019800; Glyco_hydro_3_AS.
DR   InterPro; IPR036881; Glyco_hydro_3_C_sf.
DR   InterPro; IPR001764; Glyco_hydro_3_N.
DR   InterPro; IPR036962; Glyco_hydro_3_N_sf.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR30480:SF13; BETA-HEXOSAMINIDASE; 1.
DR   PANTHER; PTHR30480; BETA-HEXOSAMINIDASE-RELATED; 1.
DR   Pfam; PF00144; Beta-lactamase; 1.
DR   Pfam; PF00933; Glyco_hydro_3; 1.
DR   PRINTS; PR00133; GLHYDRLASE3.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   PROSITE; PS00775; GLYCOSYL_HYDROL_F3; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000313|EMBL:EON76448.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EON76448.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000013909}.
FT   DOMAIN          62..377
FT                   /note="Glycoside hydrolase family 3 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00933"
FT   DOMAIN          614..978
FT                   /note="Beta-lactamase-related"
FT                   /evidence="ECO:0000259|Pfam:PF00144"
SQ   SEQUENCE   1004 AA;  111366 MW;  D4A1F9C531A4E540 CRC64;
     MDPASTQLSR LKMRLFINFF ALSAFLVGLV GSAFAQDHSI PFLNLEAEKE KWVEEAYLSL
     SLEEKIAQLI MIPVYSNKDK VHIDSVSNLV KRYRIGGMIF FQGGPVRQAQ MINRFQQESK
     VPLMISIDGE WGLAMRLDST LRFPFQMALG AVRNDSLIYE MGREIARQSK RAGLHVNFAP
     VVDINNNPAN PVIGFRSFGE DKERVSKKGV AYMSGMQDEM VLASAKHFPG HGDTNVDSHY
     GLPVIHFSKE RLHELELYPF RKLMEQGLGS VMVAHMHIPV YDNTPNLAST LSKSVVTGLL
     KEEMGYEGLV FTDALNMQGV ASYYEPGVVD VKALLAGNDM LLNTMDVPAT ITEVKKAIES
     GDITGEELDR RVLKVLKAKA WLGLDNWEPI NTSSLVSDLN APYARHLSRQ LAAASLTVLK
     NKDSVLPLKN LDTRRTASVA LGSATLTSFQ QGLDRYQRLD HFYLPKDADR NKLVNLLNGL
     EGYDRIVIGV HGVSLRAGSD RFGITPEMNL LLKELNNTKE VVICVFGNVY ALNELVDLPQ
     SAAVIAAYQE TADTQDLVSQ LVFGGIGATG TLPVALSSVF PLGAGMELEG GIRVSYGMPE
     SVGVRSEQLA GIDSLVQLAI RERATPGAQV LIAKGGRIFF HKAYGHHNYE LAREVSIDDL
     YDLASITKIS TALAALMHLQ GEGKFDENET LGHYLPMARG TNKESLVYRD ILTHQAGLTA
     WISFWQATQR KNGRFRWYTF KQDSSLRFPA RVADKLYIHR KYGDKIYREI MDSKVDPSQG
     YVYSDLSFIL APKVVESITG MDMEFYLRSN IYQPLGADGL TFNPYRVFPA TQIVPTEYDS
     LFRRQLLHGT VHDEGAAMLG GISGHAGLFG SANELSKLMH LYLNDGRYGG ESLIKPGVVR
     KFSKCVFCET SGNFRALGFD RPSRPGDPNG NAAASAPVTS FGHSGFTGTY IWIDPENELV
     YVFLSNRVHP TRENRKLYQL NIRTGILEEV YQALKANGLY KSGN
//