ID   R8H0E4_BACCE            Unreviewed;       623 AA.
AC   R8H0E4;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|Pfam:PF13676};
GN   ORFNames=IIC_05774 {ECO:0000313|EMBL:EOO66315.1};
OS   Bacillus cereus VD021.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=1053224 {ECO:0000313|EMBL:EOO66315.1, ECO:0000313|Proteomes:UP000014040};
RN   [1] {ECO:0000313|EMBL:EOO66315.1, ECO:0000313|Proteomes:UP000014040}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VD021 {ECO:0000313|EMBL:EOO66315.1,
RC   ECO:0000313|Proteomes:UP000014040};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Feldgarden M., Van der Auwera G.A., Mahillon J., Duprez V., Timmery S.,
RA   Mattelet C., Dierick K., Sun M., Yu Z., Zhu L., Hu X., Shank E.B.,
RA   Swiecicka I., Hansen B.M., Andrup L., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Bacillus cereus VD021.";
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOO66315.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AHES01000076; EOO66315.1; -; Genomic_DNA.
DR   RefSeq; WP_016103244.1; NZ_KB976285.1.
DR   AlphaFoldDB; R8H0E4; -.
DR   PATRIC; fig|1053224.3.peg.5807; -.
DR   HOGENOM; CLU_454708_0_0_9; -.
DR   Proteomes; UP000014040; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR041197; LD_cluster3.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   Pfam; PF18180; LD_cluster3; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
PE   4: Predicted;
FT   DOMAIN          147..235
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|Pfam:PF13676"
SQ   SEQUENCE   623 AA;  71176 MW;  90F89BEEACAC8731 CRC64;
     MTAYIIHPKI TFSETPQAVR FYEKCLDELL QHVPTQNILT DEVMEGITLQ KEDVVIFFNN
     NQNYPVFVID FLEDAVAAGS ELLPVAMRRD DRVPPSCVKK AQSFDVTEQL RQRSLSESHI
     ETVAIVLART VISILQPTLT KNNMYLFLSH RRIDGEKIAG AFYDAFALRA QQAFRDLNKV
     LVGEDAQEVI EENLRQCDAV VYLDTPRSGE SKWIALELEV ALSRGVPIVW VRIGPEEGRA
     KDFWFKPAEV PHFHFPNIES LDEYVDPEIV DEVIHKAFEI SRAHAKEVLG HLKRIRALAK
     RGTIKLTELN KKYFTYQIEI PRHGFRYFQR PMTHIVSFYG RLPKEHEHEQ FLKSVARYGY
     EPHPQLGTIY DTALILAPIA SQHDERLLEE PHKVDSCDEY LNCLEHYVRF PIQSQTSMKG
     IIISGAFPDC EPEHQQHITD AVRAFTQAIL TRNSKVIFGA HPTFQHLIFD MAKQINSQSY
     KDAVKMYVSR HFVKEEDVIG SRKHATVMPV DEVDKDRNKS LSAMRKSMID DPDALCMVVI
     GGKTKRHGIP PGIDEEIKLA RSRRLPVFLI GSAGGRTAEI TAEMDADDWN QNLNDLPSEF
     NHELMVSLDY SALANDILDK MGL
//