ID R9J2E5_9FIRM Unreviewed; 1083 AA.
AC R9J2E5;
DT 24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2013, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=alpha-L-rhamnosidase {ECO:0000256|ARBA:ARBA00012652};
DE EC=3.2.1.40 {ECO:0000256|ARBA:ARBA00012652};
GN ORFNames=C804_04476 {ECO:0000313|EMBL:EOS25377.1};
OS Lachnospiraceae bacterium A4.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=397291 {ECO:0000313|EMBL:EOS25377.1, ECO:0000313|Proteomes:UP000014118};
RN [1] {ECO:0000313|EMBL:EOS25377.1, ECO:0000313|Proteomes:UP000014118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4 {ECO:0000313|EMBL:EOS25377.1,
RC ECO:0000313|Proteomes:UP000014118};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Lachnospiraceae bacterium A4.";
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing alpha-L-rhamnose residues
CC in alpha-L-rhamnosides.; EC=3.2.1.40;
CC Evidence={ECO:0000256|ARBA:ARBA00001445};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EOS25377.1}.
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DR EMBL; ASSR01000104; EOS25377.1; -; Genomic_DNA.
DR AlphaFoldDB; R9J2E5; -.
DR STRING; 397291.C804_04476; -.
DR PATRIC; fig|397291.3.peg.4607; -.
DR eggNOG; COG3250; Bacteria.
DR eggNOG; COG3387; Bacteria.
DR HOGENOM; CLU_002926_1_1_9; -.
DR OrthoDB; 9761045at2; -.
DR Proteomes; UP000014118; Unassembled WGS sequence.
DR GO; GO:0030596; F:alpha-L-rhamnosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR016007; Alpha_rhamnosid.
DR InterPro; IPR035396; Bac_rhamnosid6H.
DR InterPro; IPR035398; Bac_rhamnosid_C.
DR InterPro; IPR013737; Bac_rhamnosid_N.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR008902; Rhamnosid_concanavalin.
DR PANTHER; PTHR33307:SF10; ALPHA-L-RHAMNOSIDASE; 1.
DR PANTHER; PTHR33307; ALPHA-RHAMNOSIDASE (EUROFUNG); 1.
DR Pfam; PF05592; Bac_rhamnosid; 1.
DR Pfam; PF17389; Bac_rhamnosid6H; 1.
DR Pfam; PF17390; Bac_rhamnosid_C; 1.
DR Pfam; PF08531; Bac_rhamnosid_N; 1.
DR PIRSF; PIRSF010631; A-rhamnsds; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000014118};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1083
FT /note="alpha-L-rhamnosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004483901"
FT DOMAIN 370..518
FT /note="Bacterial alpha-L-rhamnosidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08531"
FT DOMAIN 548..656
FT /note="Alpha-L-rhamnosidase concanavalin-like"
FT /evidence="ECO:0000259|Pfam:PF05592"
FT DOMAIN 661..993
FT /note="Alpha-L-rhamnosidase six-hairpin glycosidase"
FT /evidence="ECO:0000259|Pfam:PF17389"
FT DOMAIN 1001..1067
FT /note="Alpha-L-rhamnosidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17390"
SQ SEQUENCE 1083 AA; 121139 MW; 7512936D7CE838E6 CRC64;
MRRKNKRNIL AAAAVAALLC CGCSGQEPLS ENTAGEEETC KIIDLTVNYM QNPIGIEQNP
LFGWRMQAKC GQQQTAYRIV VAASQEKLAQ EEYLWDSGRT ESGSSVAVPY QGNNLLAGTG
YVWKVFVWDE AGNMTESMET AAFETGLTDN DWGGASWIGI RAEQDTKEAA KEKTYYAIEY
DVRLGRTRSG VVWGMDTNQY GDYFRCEFDT LGDTVSFSIV SLSNVDEIKR SSADLEEGLS
EDFGEKVHHV RLEIKDTAVE ASIDGKPVLH TELDQKKALG NLGFWTDRGA YYAYYDNLCV
TDGDTGEVLL QEDFEEDTSG QKKNTLFSPY YFKVRDGWCE ASSGFLLTPG VNEPAPMLRC
LFEKKPDCCV TAARLYVSAL GDYRIYLDGE EASGEYLAPG RSIYSKEVYY QTYDVTKLLA
DEQTQHVLGA ALGHGRYDKA NADWGEQIAL QAKLVLQYDD HSTQCIVTDD TWQAYADGPI
QNDDMFLGEF YDATREQTGW CERGFAADGW QQADVFSEYD ALEKRASGVP AVSCIETRKP
VAVSEPVSGV YVYDFGQNFN GNCELVFRDT EGKRGQTVTI RYAEALNDSR MSCRDDAVGT
VWTQNLYTAK NTDYYVMSGA GEETYTPKLV CRGFRYVQIS GVDEALPAEE VTGLVLSTKN
KRTGYFTCSD EHINQLYESI YWTQLSNFLD VPTDCPQRDE RFGWAGDAQV FARTAAYNAE
VHNYLSKYVQ MLIDGQCENG AFPEIAPSIN MDSGANGWSD AGIILVWELY QQYGDQRLIE
DNLQAMCRYM DYLVDTSENF VRRQHNYSDH NAVAGLEDEI ANTAQCAYVA GLLSKMSADI
GEKEIALTYE KVYNQYRAAW QENYINEDGS IDCWLQSAYT LGLAYGLYPE ELAKKGAACL
NNAVMANDYH LNTGYIGTQF LLPVLCRYGY VDTAYRILQQ DTYPSWRNML SYGQTTITEA
WNTCYETGDG TYAVNGSMNH FGLGTVGQWL YSDVLGIKRD LDNPGYKHFY IEPQVGGGLT
HVSGSYESVY GTIESGWRLE GGELVFTFVI PPNTTATVTL PDPQYQNMAL AAGAYEYRIA
LNQ
//
