ID   R9J8V1_9FIRM            Unreviewed;       714 AA.
AC   R9J8V1;
DT   24-JUL-2013, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2013, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Glutamine synthetase {ECO:0000256|ARBA:ARBA00021364};
GN   ORFNames=C806_00034 {ECO:0000313|EMBL:EOS27587.1};
OS   Lachnospiraceae bacterium 3-1.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=397288 {ECO:0000313|EMBL:EOS27587.1, ECO:0000313|Proteomes:UP000014188};
RN   [1] {ECO:0000313|EMBL:EOS27587.1, ECO:0000313|Proteomes:UP000014188}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3-1 {ECO:0000313|EMBL:EOS27587.1,
RC   ECO:0000313|Proteomes:UP000014188};
RG   The Broad Institute Genomics Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Earl A., Xavier R., Elson C., Duck W., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Lachnospiraceae bacterium 3-1.";
RL   Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glutamine synthetase family.
CC       {ECO:0000256|PROSITE-ProRule:PRU01330, ECO:0000256|RuleBase:RU000384}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EOS27587.1}.
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DR   EMBL; ASST01000001; EOS27587.1; -; Genomic_DNA.
DR   AlphaFoldDB; R9J8V1; -.
DR   STRING; 397288.C806_00034; -.
DR   PATRIC; fig|397288.3.peg.38; -.
DR   eggNOG; COG3968; Bacteria.
DR   HOGENOM; CLU_024307_0_0_9; -.
DR   Proteomes; UP000014188; Unassembled WGS sequence.
DR   GO; GO:0004356; F:glutamine synthetase activity; IEA:InterPro.
DR   GO; GO:0006542; P:glutamine biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.20.120.1560; -; 1.
DR   Gene3D; 3.30.590.10; Glutamine synthetase/guanido kinase, catalytic domain; 1.
DR   InterPro; IPR040577; Gln-synt_C.
DR   InterPro; IPR008147; Gln_synt_N.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   InterPro; IPR008146; Gln_synth_cat_dom.
DR   InterPro; IPR027303; Gln_synth_gly_rich_site.
DR   InterPro; IPR022147; GSIII_N.
DR   PANTHER; PTHR42974; GLUTAMINE SYNTHETASE; 1.
DR   PANTHER; PTHR42974:SF1; TYPE-3 GLUTAMINE SYNTHETASE; 1.
DR   Pfam; PF00120; Gln-synt_C; 1.
DR   Pfam; PF18318; Gln-synt_C-ter; 1.
DR   Pfam; PF12437; GSIII_N; 1.
DR   SMART; SM01230; Gln-synt_C; 1.
DR   SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
DR   PROSITE; PS00181; GLNA_ATP; 1.
DR   PROSITE; PS51986; GS_BETA_GRASP; 1.
DR   PROSITE; PS51987; GS_CATALYTIC; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014188}.
FT   DOMAIN          75..169
FT                   /note="GS beta-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS51986"
FT   DOMAIN          174..605
FT                   /note="GS catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS51987"
FT   COILED          638..665
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   714 AA;  78867 MW;  EA80B84B0965A7EA CRC64;
     MPFFGKDVGN MSGYYNVAEI FGENVFNDAV MQERLPKKVY KRLKDVISEG RELDLETADV
     VAHEMKEWAI EKGATHYTHW FQPLTGVTAE KHDSFITAPM ANGKVLMSFS GKELIKGEPD
     ASSFPSGGLR ATFEARGYTA WDCTSPAFVR QDAAGATLCI PTAFCSYTGE ALDQKTPLLR
     SMEAINVQSL RLLRLFGNTT SKKVTPSVGP EQEYFLVDRE KYLKRKDLIF TGRTLFGAMP
     PKGQEMDDHY FGAIRERIAA YMRDVNKELW KLGVTAKTQH NEVAPAQHEL APIYAEANVA
     VDNNQLVMET LKKVAGRHGM TCLLHEKPFA GVNGSGKHNN WSIITDDGIN LLDPGKTPHD
     NIQFLLVLTC ILKAVHKHAD LLRESAADAG NDHRLGANEA PPAIISVFLG EQLQDVLTQL
     ISTGEATRSL KGEVLQTGVK TLPDFMKDAT DRNRTSPFAF TGNKFEFRMV GSTDSVAAPN
     VVLNTIVAEA FSDASDVLEK ADDFEMAVHN LIKEQATDHQ DIVFNGNGYS PEWVEEAERR
     GLPNITNMVD AVPALVTDKA IALFEKFNVF TEAELKSRSE ILYESYAKAI NIEARAMIDM
     AGKQIIPAVI KYTTALANSI NSVKAACDAD VSVQTELLKD VSALLAEAKA ALKKLEEVAE
     KAYAMEEGRA QAICYRDEVK VSMEALRAPV DKLEMIVDKE MWPMPSYGDL IFEV
//